“芪香”口服液抗呼吸道感染的主要药效学研究

目的:观察"芪香"口服液抗呼吸道感染主要药效学作用。方法:采用家兔致热反应后的体温变化,观察"芪香"口服液的解热作用;采用小鼠耳廓肿胀试验,观察"芪香"口服液的抗炎作用;采用小鼠热板试验,观察"芪香"口服液的镇痛作用;采用体外抑菌实验,观察"芪香"口服液对常见呼吸道细菌的抑菌作用。结果:"芪香"口服液对内毒素所致家兔发热模型具有退热作用,能抑制二甲苯所致小鼠耳廓炎性肿胀;可明显提高热板引起的小鼠痛阈值;对呼吸道常见的病原菌有一定的抑菌作用。结论:"芪香"口服液是抗呼吸道感染的有效药物,具有显著的解热、抗炎、镇痛、抗菌的作用。

Study on Pharmacodynamics of Qixiang Oral Liquid in Anti-respiratory Tract Infection

Objective:The experiment intends to observe the pharmacodynamics of Qixiang Oral Liquid,a herbal compound preparation made from Huangqi(Radix Astragali),Xiangru(Herba Moslae),and Bohe(Herba Menthae),in anti-respiratory tract infection.Methods:The fever-relieving of Qixiang Oral Liquid with rabbits' temperature changes caused by pyogenicity was observed;anti-inflammatory effect of was observed by the test of auricle swelling in mice;pain-relieving was by hot plate test in mice;bacteriostasis to common seen respiratory tract bacteria was observed by anti-bacteria test in vitro.Results:Qixiang Oral Liquid could relieve fever in fever rabbit model caused by endotoxin,inhibit auricle swelling caused by xylene,significantly increase pain threshold caused by hot plate test,and work to bacteriostasis for common seen bacteria in respiratory tract.Conclusion:Qixiang Oral Liquid,an effective medicine in anti-respiratory tract infection,has actions to relieve fever,anti-inflammation,relieve pain and antibiosis.