| 补肾抗衰汤影响秀丽隐杆线虫衰老的机制研究 |
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| 引用本文： | 史爱武,陆勤,侯莉莉,陈军霞,曹新国.补肾抗衰汤影响秀丽隐杆线虫衰老的机制研究[J].辽宁中医杂志,2013(1):52-54. |
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| 作者姓名： | 史爱武 陆勤 侯莉莉 陈军霞 曹新国 |
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| 作者单位： | 南京医科大学附属南京妇幼保健院 |
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| 基金项目： | 南京市医学科技发展项目(YKK09086);南京医科大学科技发展基金项目(2011NJMU214) |
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| 摘 要： | 目的:探讨补肾抗衰汤对秀丽隐杆线虫衰老的影响。方法:观察野生型N2与daf-2、daf-16突变体线虫在不同浓度(50%、75%与100%)补肾抗衰汤干预下寿命变化,并分析补肾抗衰汤干预下线虫daf-2与daf-16基因表达的变化。结果:高浓度补肾抗衰汤干预可以显著延长N2、daf-2、daf-16突变体线虫的寿命(P<0.01);增加daf-16的基因表达并降低daf-2的基因表达。结论:高浓度补肾抗衰汤干预通过影响daf-2与daf-16基因表达延缓秀丽线虫的衰老。
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| 关 键 词： | 补肾抗衰汤 秀丽隐杆线虫 衰老 机制研究 |
Mechanism Study of Bushen Kangshuai Decoction on Senescence of Caenorhabditis Elegans |
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| SHI Aiwu,LU Qin,HOU Lili,CHEN Junxia,CAO Xinguo.Mechanism Study of Bushen Kangshuai Decoction on Senescence of Caenorhabditis Elegans[J].Liaoning Journal of Traditional Chinese Medicine,2013(1):52-54. |
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| Authors: | SHI Aiwu LU Qin HOU Lili CHEN Junxia CAO Xinguo |
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| Institution: | (Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University,Nanjing 210004,Jiangsu,China) |
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| Abstract: | Objective:To investigate the effect of Bushen Kangshuai Decoction on senescence of caenorhabditis elegans.Methods:To explore the life span of N2 caenorhabditis elegans and daf-2 and daf-16 mutants incubated with different concentrations of Bushen Kangshuai Decoction and to analyse the gene expressions of daf-16 and daf-2.Results:BKT administration at higher concentrations could effectively prolong the life span of caenorhabditis elegans(N2,daf-2 and daf-16 mutant),increase the gene expression of daf-16,decrese the gene expression of daf-2 as compared with the control.Conclusion:The results indicate that Bushen Kangshuai Decoction could prevent senescence of caenorhabditis elegans through the effect of gene expressions of daf-2 and daf-16. |
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| Keywords: | Bushen Kangshuai Decoction caenorhabditis elegans senescence mechanism study |
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