美沙拉嗪缓释片的处方筛选及体外释放度研究 |
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引用本文: | 吕竹芬,谭载友,张蜀,黄宇辉,邓海燕,洪晓鹏,张燕珊.美沙拉嗪缓释片的处方筛选及体外释放度研究[J].中国现代应用药学,2000,17(6):461-463. |
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作者姓名: | 吕竹芬 谭载友 张蜀 黄宇辉 邓海燕 洪晓鹏 张燕珊 |
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作者单位: | 广东药学院,广州,510224 |
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摘 要: | 目的:制备美沙拉嗪缓释片剂,并评价其体外释放特性。方法:用正交试验设计对片剂的处方进行筛选,制备美沙拉嗪缓释片剂,测定其释放特性。结果:以优选的处方所制备的片剂,体外释药性能符合Higuchi模型,持续释药达8h。结论:该片剂工艺简单,可适合工业化生产。
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关 键 词: | 美沙拉嗪 缓释片 处方 正交试验 释放度 |
Prepaeration and release of sustained release mesalazine tablets |
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Abstract: | OBJECTIVE:To prepare sustained release tablets and evaluate its drug release property.METHOD:The formulation of the tablet was found by orthogonal design test.RESULTS:The release rate of the prepared tablets conformed to Higuchi equation and the drug was |
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Keywords: | mesalazine sustained release tablets formulation orthogonal design release rate |
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