间充质干细胞的研究进展与临床应用前景

目的 介绍间充质干细胞（mesenchymal stem ceils，MSCs）的研究进展及其临床成用前景。方法 查阅国内外近年有关文献，并行综合分析。结果 由于MSCs能分化为多种类型的细胞，所以在细胞移植治疗和组织工程方面有广泛的应用。由于其能稳定表达转染到细胞内的目的基因。可治疗血友病、脑梗塞及骨缺损等，因此在基因治疗中应用广泛。其所具有的免疫调节特性，使它在免疫性疾病的治疗中也有广泛的用途。结论 MSCs是一种具有自我更新和多向分化潜能的干细胞，且体外易于扩增，是一种理想的细胞治疗和基因治疗的靶细胞，临床应用前景非常广阔。

RESEARCH ADVANCE AND CLINICAL APPLICATION OF MESENCHYMAL STEM CELLS

Objective To review the advance in the experimental studies and evaluate the potential therapeutic application of the mesenchymal stem cells(MSCs).Methods The related articles published in China and the other countries during the recent years were extensively reviewed and analyzed. Results The MSCs were widely used in the cell-transplantation therapy and the tissue engineering because of their pluripotency of differentiation into various kinds of cells.They were also frequently used in the gene therapy because they could stably express the transfected objective genes.Because of their immunomodulatory function,the MSCs could also be used in the immunotherapy.Conclusion The MSCs are the stem cells,which have characteristics of renewing themselves,having multipotency,and being easy to undergo amplification in vitro. The MSCs are ideal target cells for the cell therapy,tissue engineering,gene therapy,and immunotherapy.