瑞芬太尼与芬太尼复合丙泊酚用于无痛胃镜检查术后认知功能的影响

目的:观察芬太尼、瑞芬太尼分别联合丙泊酚用于门诊无痛胃镜检查时对认知功能的影响。方法:选择胃镜检查患者60例,随机均分为A、B两组。瑞芬太尼组:设定瑞芬太尼血浆靶浓度为2.5ng/ml,靶控输注瑞芬太尼30s后匀速静注丙泊酚1.5mg/kg;芬太尼组:静注芬太尼50μg后,90s内均速静注丙泊酚1.5mg/kg。当患者对言语指令无反应和睫毛反射消失时置入胃镜,SpO2始终保持在90%以上。全部患者于胃镜检查结束拔镜后5min行神经行为认知状态检查(NCSE),并在15min内完成。结果:60例患者均完成胃镜检查后进行NCSE测试,两组间比较,计算能力及记忆能力差异有统计学意义(P<0.05)。结论:瑞芬太尼加丙泊酚1.5mg/kg用于门诊无痛胃镜检查,不仅提供满意的镇痛效果和检查条件,而且对认知功能无影响。

Effect of Propofol Combined with Remifentanil or Fentanilfor on Cognitive Function in Patients with Painless Gastroscopy

Objective To study the effect of propofol combined with Remifentanil or fentanil for outpatient painless gastroscopy on cognitive function. Methods Sixty patients scheduled for gastroscopy were randomly divided into group A and group B. Group A: Remifentanil was given 2.5 ng/kg intravenously before gastroscope insertion, and propofol 1.5 mg/ kg followed 30 seconds later. Group B: 50 μg fentanil was given followed by propofol 1.5 mg/kg 90 seconds later. The gastroscope was inserted when patient showed uncons...