阴道侵袭性血管黏液瘤临床病理观察

目的：探讨侵袭性血管黏液瘤（aggressive angiomyxoma,AAM）的临床病理特征。方法：回顾性分析1例侵袭性血管黏液瘤的临床病理学资料。结果：采取手术治疗,术中见：肿瘤无包膜,剖面均一灰白色、胶质样,有黏液性间质分隔。病检示：镜下见瘤细胞呈梭形或星形疏松排列于黏液间质背景中,有厚壁血管。免疫组化显示：Vimentin（＋）,Actin（＋）,CD34（＋）,HMB45（-）,S-100（-）,Myoqlobin（-）。结论：AAM是一种罕见的、局部浸润性间质肿瘤。侵袭性、复发性是其重要特征,需提高首次诊断的正确性,首次治疗以局部广泛切除为宜,且需长期随访监测。

Clinical and pathological analysis of aggressive angiomyxoma

Objective：To discuss the clinical pathological features of aggressive angiomyxom（AAM）.Methods：A retrospective analysis was made to the clinical pathological data of a cases with AAM.Results：In the operation,it was seen that the tumor had no peplos,the section of the tumor was homogeneous gray and colloidal,with dissection of nmcilaginous stroma.The pathological study revealed that the tumor cells were spindle-shaped or starshaped,loosely ringing in the mucilaginous stroma with thick-walled vessels,the cell nucleus had no mitogen activation;immunohistochemical study showed positive vimentin,actin and CD34,and negative HMB45,S-100 and Myogqlobin.Conclusion：AAM is a rare local infiltrating mesenchymal neoplasm.with the features of infiltration and recurrence.It is important to raise the correct preliminary diagnosis rate;the preliminary treatment is local wide excision,and long-term follow-up is needed.