影响体外受精-胚胎移植临床结局多因素分析

目的:分析不同年龄不孕妇女接受体外受精-胚胎移植(IVF-ET)的结局,探讨与治疗结局相关的若干因素,从而为不孕患者制定个性化助孕方案提供依据。方法:回顾性分析2007年7月～2008年12月接受IVF-ET治疗的327例患者的临床资料。结果:按年龄≤25岁、26岁～、30岁～、35岁～和40岁～将患者分组进行比较,着床率和妊娠率随着年龄的增加逐渐下降(P<0.05);<35岁与≥35岁两组患者间可利用胚胎数、优质胚胎数等方面差异有统计学意义(P<0.05);将可能影响获卵数的各种因素进行单因素线性回归分析,其中年龄、基础FSH、FSH/LH与获卵数呈显著负相关(P<0.01)。结论:年龄是影响女性生育能力的主要因素,随着年龄的增加,卵巢反应性逐渐降低,着床率和妊娠率也随之降低,不同年龄患者应制定个性化的治疗方案以提高临床妊娠率。

Multivariate analysis on effect factors of clinical outcomes of in vitro fertilization and embryo transfer

Objective:To analyze the outcomes of in vitro fertilization and embryo transfer(IVF-ET) of infertile women in different ages,explore related effect factors of therapeutic outcomes,provide a basis for instituting personalized therapies.Methods:Clinical data of 327 infertile women undergoing IVF-ET from July 2007 to December 2008 were analysed retrospectively.Results:All the patients were divided into five groups according to age(≤25,26～,30～,35～ and 40～),the rates of nidation and pregnancy declined with age(P<0.05);there was significant difference in amounts of available embryos and high quality embryos between <35 years group and ≥35 years group(P<0.05);linear regression indicated that there was a negative correlation between age,basal follicle stimulating hormone(FSH) level,FSH/ luteinizing hormone(LH) and oocytes per retrieval(P<0.01).Conclusion:Age is a main effect factor of female reproduction,the ovarian reactivity as well as the rates of nidation and pregnancy declines gradually with age,personalized therapies according to age should be made to improve clinical pregnancy rate.