Association study on the NAPG gene and bipolar disorder in the Chinese Han population |
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Authors: | Xingwang Li Jing Zhang Yang Wang Jue Ji Fengping Yang Chunling Wan Peng Wang Guoyin Feng Klaus Lindpaintner Lin He Guang He |
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Affiliation: | 1. Bio-X Center, Key Laboratory of Developmental Genetics and Neuropsychiatric Diseases, Ministry of Education, Shanghai Jiao Tong University,1954 Hushan Road, Shanghai 200030, PR China;2. Institutes of Biomedical Sciences, Fudan University, 138 Yixueyuan Road, Shanghai 200032, PR China;3. Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, PR China;4. Wuhu No. 4 People''s Hospital, Jiulong, Matang District, Wuhu 241002, PR China;5. Shanghai Institute of Mental Health, 600 South Wan Ping Road, Shanghai 200030, PR China;6. Bio-X Life Science Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, PR China;g Roche (China) Ltd., 1100 Long Dong Avenue, Pudong New Area, Shanghai 201203, PR China |
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Abstract: | Background: Bipolar disorder is a mental health problem throughout the world. Chromosome 18p11 has been identified by several studies as a susceptiblilty region for bipolar disorder and NAPG, located on 18p11, has been suggested as being associated with bipolar disorder in European population. Methods: Our study employed five SNPs (rs2290279, rs495484, rs510110, rs617040 and rs473938) to investigate the role of NAPG in the Chinese Han population based on a sample of 465 controls vs. 499 bipolar patients. Results: Rs617040 was excluded from further analysis because of deviation from Hardy–Weinberg equilibrium. Rs473938 and rs2290279 showed significant association in both allele and genotype frequencies (rs473938: allele p = 0.0028 after 100,000 permutations, genotype p = 0.0018; rs2290279: allele p = 0.0042 after 100,000 permutations, genotype p = 0.0028). Several combinations of haplotype were found to be associated with bipolar disorder. Haplotype T–A–T of rs473938–rs2290279–rs495484 was defined by confidence intervals algorithm and had a p value of 0.0038 after 100,000 permutations. Conclusions: Our study supports NAPG as a candidate for susceptibility to bipolar disorder. |
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Keywords: | Association NAPG Bipolar disorder |
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