Motor cortical organization in an adult with hemimegalencephaly and late onset epilepsy |
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Authors: | Carlo Civardi Roberta VicentiniAlessandra Collini Cristina BoccagniRoberto Cantello Francesco Monaco |
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Institution: | Department of Medical Sciences, Section of Neurology, Università del Piemonte Orientale A. Avogadro, Novara, Italy |
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Abstract: | Hemimegalencephaly is a rare brain malformation whose physiology is largely obscure. In a single patient, we studied motor cortex using several transcranial magnetic stimulation variables testing cortical excitability, and mapping motor area. The megalencephalic hemisphere showed an enlargement of cortical motor map with abnormal axonal orientation and an excess spread of corticospinal excitation, associated with multiple defects of cortical inhibition. TMS gave new information on the anatomic/functional features and epileptogenesis in this complex and physiologically obscure syndrome. |
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Keywords: | Transcranial magnetic stimulation Hemimegalencephaly Cortical dysplasia Cortical excitability Brain mapping |
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