Activation of muscarinic M-3 receptor may decrease glucose uptake and lipolysis in adipose tissue of rats |
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| Authors: | Ting-Ting Yang Cheng-Kuei Chang Chiung-Wen Tsao Ya-Mei Hsu Chao-Tien Hsu Juei-Tang Cheng |
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| Affiliation: | 1. Graduate Institute of Basic Medical Science, China Medical University, Taichung City, Taiwan, ROC;2. Department of Surgery, Mackay Memorial Hospital, and Graduate Institute of Injury Prevention and Control, Taipei Medical University, Taipei City, Taiwan, ROC;3. Department of Nursing, Chung Hwa University of Medical Technology, Tainan County, Taiwan, ROC;4. Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan, ROC;5. Department of Pathology, E-Da Hospital/I-Shou University, Yan-Chau Shiang, Kaohsiung Shan, Taiwan, ROC;6. Chi Mei Medical Center, Yung Kang City, Tainan Shan, Taiwan, ROC |
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| Abstract: | Role of muscarinic receptor in the regulation of glucose uptake or lipolysis in adipose tissue remained unclear. In epididymal white adipose tissue (WAT) isolated from Wistar rats, we observed that acetylcholine (ACh) attenuated the insulin-stimulated glucose uptake and the release of glycerol from WAT in a concentration-dependent manner. Using the blockade of specific antagonists, both actions of ACh were characterized mainly due to an activation of M3 receptors. In the presence of various inhibitors for PLC–PKC pathway, ACh-decreased glucose uptake was also reversed. Taken together, these results suggest that muscarinic M3 receptor is involved in the regulation of glucose uptake and/or lipolysis in adipose tissue. |
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| Keywords: | Adipose Muscarinic receptor Acetylcholine Glucose uptake Lipolysis |
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