Negative BOLD effect on somato-motor inhibitory processing: An fMRI study |
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| Authors: | Hiroki Nakata Kiwako Sakamoto Antonio Ferretti Mauro Gianni Perrucci Cosimo Del Gratta Ryusuke Kakigi Gian Luca Romani |
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| Institution: | 1. ITAB-Institute for Advanced Biomedical Technologies, Gabriele D’Annunzio University Foundation, Chieti, Italy;2. Department of Clinical Sciences and Bio-imaging, Gabriele D’Annunzio University, Chieti, Italy;3. Department of Integrative Physiology, National Institute for Physiological Sciences, Okazaki, Japan;4. Department of Physiological Sciences, School of Life Sciences, The Graduate University for Advanced Studies, Hayama, Kanagawa, Japan |
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| Abstract: | Inhibiting inappropriate behavior and thoughts in the current context is an essential ability for humans, but the neural mechanisms for response inhibitory processing are a matter of continuous debate. The aim of this event-related functional magnetic resonance imaging (fMRI) study was to evaluate the negative blood oxygen level dependent (BOLD) effect on inhibitory processing during go/no-go paradigms. Fifteen subjects performed two different types of somatosensory go/no-go paradigm: (1) button press and (2) count. Go and no-go stimuli were presented with an even probability. We observed a common negative activation during Movement No-go and Count No-go trials in the right SFG, corresponding to BA 8. These findings suggest that the right SFG region was responsible for the negative BOLD effect on inhibitory processing, which was independent of the required response mode. We hypothesized several possible explanations for the deactivation of the SFG during no-go trials. |
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| Keywords: | Functional magnetic resonance imaging Somatosensory Response inhibition Go/no-go No-go |
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