In vitro effect of trifluoperazine on human lymphocytes |
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| Authors: | A Suryanarayana P Rita P P Reddy |
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| Affiliation: | Institute of Genetics, Osmania University, Begumpet, Hyderabad, Aandra Pradesh, India. |
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| Abstract: | Trifluoperazine, a phenothiazine group of tranquilizer was studied for its chromosome damaging effect in human lymphocyte cultures. The cells were treated with 10, 15 and 20 micrograms/culture of trifluoperazine for 24, 48 and 72 hours. A high incidence of chromatid breaks and gaps was observed after 48 and 72 hours treatment. The study revealed that the drug acts mostly on the late S and G2 phase of the cell cycle. |
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