CK技术判断顿抑心肌程度的实验研究

目的：本研究旨在评价彩色室壁动力分析（ＣｏｌｏｒＫｉｎｅｓｉｓ，简称ＣＫ）技术判断顿抑心肌程度的价值。建立８条犬心肌顿抑模型，根据冠状动脉结扎时间的不同将其分为两组。超声检查结果与核素心肌灌注显像和病理检查比较。发现（１）比较心肌顿抑节段３０和６０分钟时收缩期和舒张期心内膜ＣＫ彩色宽度，并分别与非缺血心肌节段心内膜ＣＫ宽度比较，差别均有显著性意义（ｐ均＜００１）。（２）比较冠状动脉结扎３０和６０分钟ＳＰＥＣＴ收缩和舒张期缺血心肌区内放射性计数与峰计数的比值，并分别与３０和６０分钟心肌顿抑节段收缩期和舒张期心内膜ＣＫ色带宽度进行比较，发现其高度相关（ｐ均＝０００１）。本研究表明ＣＫ的色带宽度可以反映短暂心肌缺血再灌注后心肌顿抑的程度，心肌缺血的时间越长心肌顿抑的程度越重，可能为预测心肌顿抑的持续时间提供依据

Experimental Study for Displaying the Extend of Stunned Myocardium by Color Kinesis Technique

Purpose:The purpose of this study was evaluated the ability of displaying the extent of stunned myocardium by new-developes CK technique. Eight stunned myocardial models were studied by CK and trinitrate Techetium-99m sestamibi imaging ( 99 Tc-SPECT) after coronary artery ligating 30-60 min. Results: (1) CK color width of stunned segments in systole and diastole after coronary artery ligating 30-60 min were less than normal (p<0 001). (2)The extent correlation was between radioactivity of 99 Tc-MIBI in myocardial ischemia segments at coronary artery ligation and CK color width of stunned myocardium segments in systole and diastole after release temporary coronary artery occlusions (p=0 001). Conclusion: CK color width maybe reflect the extend of stunned myocardiun and foretell the duration of myocardium stunned.