Age modify the associations of obesity,physical activity,vision and grip strength with functional mobility in Irish aged 50 and older |
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| Affiliation: | 1. Department of Medical Gerontology, School of Medicine, Trinity College Dublin, Old Stone Building, Trinity Centre for Health Sciences, St James''s Hospital, James''s Street, Dublin 8, Ireland;2. The Irish Longitudinal Study on Ageing (TILDA), Lincoln Gate, Trinity College Dublin, College Green, Dublin 2, Ireland;3. Macular Pigment Research Group, Vision Research Centre, Carriganore House, Waterford Institute of Technology, Waterford, Ireland;4. Head of Reading Centre, Department of Research and Development, National Institute of Health Research Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom;5. Discipline of Medical Gerontology, School of Medicine, Trinity College Dublin, Old Stone Building, Trinity Centre for Health Sciences, St James''s Hospital, James''s Street, Dublin 8, Ireland;1. Department of Medical Gerontology, School of Medicine, Trinity College Dublin, The University of Dublin, Old Stone Building, Trinity Centre for Health Sciences, St James''s Hospital, James''s Street, Dublin 8, Ireland;2. The Irish Longitudinal Study on Aging (TILDA), Lincoln Gate, Trinity College Dublin, The University of Dublin, College Green, Dublin 2, Ireland;3. Department of Optometry and Visual Science, College of Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana;4. Head of Reading Centre, Department of Research and Development, National Institute of Health Research Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom;5. Macular Pigment Research Group, Vision Research Centre, Carriganore House, Waterford Institute of Technology, Waterford, Ireland |
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| Abstract: | ObjectiveTo estimate whether the associations of obesity, physical activity, vision and grip strength with functional mobility were modified by age.MethodsData from The Irish Longitudinal Study on Ageing (2009–2012) were analyzed and 5001 individuals were included in this study. Mobility was assessed by the timed up and go test (TUG-test). Main exposure variables were obesity, physical activity, visual acuity and grip strength at baseline. Multiple linear regression models were fitted to assess the associations of baseline main exposure variables with 2-year follow-up functional mobility and potential confounders were adjusted. Stratified analyses by age were used to assess the interaction between main exposures and age on functional mobility.ResultsMultiple linear regression models identified significant interactions of obesity (P < 0.001), vigorous physical activity (P = 0.001), vision (P < 0.001) and grip strength (P < 0.001) with age on functional mobility. Stratified analyses suggested that the risk effect of obesity on functional mobility was greater in middle-aged group (β = 0.025, P < 0.001) than in older group (β = 0.016, P = 0.017). The protective effects of high level of physical activity and grip strength on functional mobility were stronger in older group (β = −0.023, P = 0.004 for physical activity; β = −0.002, P < 0.001 for grip strength) than in middle-aged group (β = −0.012, P = 0.008 for physical activity; β = −0.0015, P < 0.001 for grip strength). The benefit of better vision on functional mobility was observed in middle-aged group only (β = −0.032, P = 0.002).ConclusionNon-obesity, higher level of physical activity, vision and grip strength at baseline were associated with better mobility performance among middle-aged and older Irish. And these associations were modified by age. |
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| Keywords: | Effect modification Functional mobility Grip strength Obesity Physical activity Vision |
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