| 肺鳞癌患者手术前后血清VEGF-C、IL-6及MMP-2水平变化及其临床意义 |
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| 引用本文： | 彭武君.肺鳞癌患者手术前后血清VEGF-C、IL-6及MMP-2水平变化及其临床意义[J].标记免疫分析与临床,2019,26(3):494-497. |
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| 作者姓名： | 彭武君 |
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| 作者单位： | 广元市第三人民医院,四川广安,628000 |
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| 摘 要： | 目的探讨肺鳞癌(SCC)患者手术前后血清血管内皮生长因子C(VEGF-C)、白介素-6(IL-6)及基质金属蛋白酶-2(MMP-2)水平变化及其临床意义。方法将我院接诊的94例SCC患者纳入SCC组,均行手术治疗,80例同期健康体检者纳为对照组,比较两组及SCC患者手术前后血清VEGF-C、IL-6、MMP-2水平的变化,并分析其与淋巴结转移的关系。结果 SCC组血清VEGF-C、IL-6及MMP-2水平均明显高于对照组(P<0.05);SCC淋巴结转移组血清VEGF-C、IL-6及MMP-2水平明显高于SCC非淋巴结转移组(P<0.05);VEGF-C、IL-6及MMP-2的ROC曲线下面积(AUC)分别为0.793、0.729、0.670,其中VEGF-C的AUC最大;三者联合检测的灵敏度、特异性(AUC 0.861)高于VEGF-C(AUC 0.793),即三者联合检测淋巴结转移的诊断效能高于单一检测;SCC患者术前、术后7d及术后30d的血清VEGF-C、IL-6、MMP-2水平呈下降趋势(P<0.05)。结论 VEGF-C、IL-6及MMP-2三者联合检测可提高对SCC患者淋巴结转移的诊断价值,动态监测SCC患者血清VEGF-C、IL-6及MMP-2水平有助于预后判断和指导术后治疗。
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| 关 键 词： | 肺鳞癌 血管内皮生长因子C 白介素-6 基质金属蛋白酶-2 |
Changes of Serum VEGF-C,IL-6 and MMP-2 Levels Before and After Operation and Their Clinical Significances in Patients with Lung Squamous Cell Carcinoma |
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| PENG Wu-jun.Changes of Serum VEGF-C,IL-6 and MMP-2 Levels Before and After Operation and Their Clinical Significances in Patients with Lung Squamous Cell Carcinoma[J].Labeled Immunoassays and Clinical Medicine,2019,26(3):494-497. |
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| Authors: | PENG Wu-jun |
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| Institution: | (Department of Surgical,Third People′s Hospital of Guangyuan City,Guangyuan 628000,China) |
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| Abstract: | PENG Wu-jun(Department of Surgical,Third People′s Hospital of Guangyuan City,Guangyuan 628000,China) |
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| Keywords: | Lung squamous cell carcinoma Vascular endothelial growth factor C Interleukin-6 Matrix metalloproteinase-2 |
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