Effect of depressive disorder on cognitive decline |
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| Affiliation: | 1. Department of Health Administration, College of Health Science, Dankook University, Cheonan, Republic of Korea;2. Institute of Health Promotion and Policy, Dankook University, Cheonan, Republic of Korea;1. Department of Otorhinolaryngology, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden;2. Department of Cardiothoracic Surgery, Queen Silvia Children''s Hospital, Gothenburg, Sweden;3. Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, at the University of Gothenburg, Gothenburg, Sweden;1. Institut national d’études démographiques, 133, bld Davout, 75980, Paris cedex 20, France;2. École des hautes études en sciences sociales, Paris, France;3. Korea Labor Institute, 622, C Bldg, Sejong National Research Complex 370, Sicheong-daero, Sejong-si, 30147 South Korea;1. Falls, Balance and Injury Research Centre, Neuroscience Research Australia, 139 Barker Street, Randwick, NSW, 2031, Australia;2. School of Public Health and Community Medicine, University of New South Wales, Sydney, NSW, 2031, Australia;3. Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, 2031, Australia;4. Dementia Centre for Research Collaboration, University of New South Wales, Sydney, NSW, 2031, Australia;5. Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, 2052, Australia;6. Australian Institute of Health Innovation, Macquarie University, Level 6, 75 Talavera Rd, Macquarie University, NSW, 2109, Australia;7. Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, 2052, Australia |
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| Abstract: | This study longitudinally investigates the effect of depressive disorder on psychiatric disorder in middle aged and aged population from the Korean Longitudinal Study of Aging. Data from the Korean Longitudinal Study of Aging (KLoSA) from 2006 to 2016 was assessed using longitudinal data analysis and 7515 research samples were included after excluding those with cognitive decline and missing information at baseline (2006). To analyze the association between depressive disorder on cognitive decline in middle aged and aged population, generalized estimating equation (GEE) model and chi-square test were used. The association between depressive symptom during a week and center for epidemiological studies depression (CESD) on cognitive decline was statistically significant, respectively with the following Odds ratio (OR) predicting decreased MMSE score: OR = 0.89 (p < .0001) for 5–7 days vs. less than a day and B = 0.91 (p < .0001) for depression (8–10) vs. healthy (zero). In terms of cognitive decline, depressive symptom was higher for 5–7 days (OR = 3.79, p < .0001) compared to less than a day. This study shows a statistically significant association between depressive disorder and cognitive decline in a Korean middle aged and aged population. These findings suggest the importance of managing depressive disorder for incident cognitive decline. |
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| Keywords: | Aging Depression Elderly Mental health |
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