Diffusion based MR measurements correlates with age-related changes in human intervertebral disks |
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| Institution: | 1. Center for Advanced Orthopaedic Studies, Department of Orthopedics, Beth Israel Deaconess Medical Center and Harvard medical School, Boston, MA, United States;2. Department of Radiology, Beth Israel Deaconess Medical Center and Harvard medical School, Boston, MA, United States of America;1. Univ Lyon – UJM-Saint-Etienne, Inter-university Laboratory of Human Movement Science, EA 7424, F-42023 Saint-Etienne, France;2. Department of Orthopedic Surgery, University Hospital of Saint Etienne, France;3. Sydney Orthopaedic Research Institute, Sydney, Australia;1. Department for Trauma and Reconstructive Surgery, RWTH Aachen University Hospital, Pauwelsstraße 30, 52074 Aachen, Germany;2. Institute of Molecular and Cellular Anatomy, RWTH Aachen University Hospital, Wendlingweg 2, 52070 Aachen, Germany;3. Department of Dental Materials and Biomaterials Research, RWTH Aachen University Hospital, Pauwelsstraße 30, 52074 Aachen, Germany;4. Department of Diagnostic and Interventional Radiology, RWTH Aachen University Hospital, Pauwelsstraße 30, 52074 Aachen, Germany;5. Faculty of Medicine, University of Cologne, Joseph-Stelzmann-Str. 20, 50931 Cologne, Germany;6. Spine Department, Clinical Centre Leverkusen gGmbH, Am Gesundheitspark 11, Leverkusen, Germany;1. School of Chemistry, Physics and Mechanical Engineering, Science and Engineering Faculty, Queensland University of Technology, Brisbane, Australia;2. Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia;3. Department of Applied Physics, University of Eastern Finland, Kuopio, Finland;1. Unidad de Patología de Columna, Hospital Universitario Fundación Jiménez Díaz, Avda. Reyes Católicos, 2, 28040 Madrid, Spain;2. Department of Trauma Surgery, Medical University of Innsbruck, Innsbruck, Austria |
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| Abstract: | BackgroundUnderstanding the association between MR parameters and age related deterioration in human intervertebral disks forms an important step in the development of clinical diagnostic protocols for disk disease.MethodsTen unfixed thoracic and lumbar cadaver disk joints, age 37–81 years were imaged at 9.4 T using T2 relaxation (CPMG) and ADC (DWI spin echo) MR protocols. For each MR parameter, spatial maps were computed from the axial images, with the AF and NP segmented based on the T2 maps. Linear regression tested for the correlation between mean and variance (COV) of T2 and ADC with age in the disk, nucleus and annulus, and the effect of thoracic vs. lumbar spine on these correlations.FindingsIn the disk, age negatively correlated with mean ADC (P < 0.001) and positively with COV of ADC (P < 0.001) and T2 (P < 0.05). Age was negatively correlated with mean T2 (P < 0.01), mean ADC (P < 0.001) and positively with COV of ADC (P < 0.001) and T2 (P < 0.05) in the NP and positively correlated with mean T2 (P < 0.05), COV of ADC (P < 0.01) and T2 (P < 0.05) and negatively with mean ADC (P < 0.05) in the AF. Compared to thoracic disks, lumbar disks showed higher mean ADC (P < 0.05), lower mean T2 (P < 0.001) and higher COV of ADC (P < 0.01) and T2 (P < 0.05).InterpretationCompared to T2, MR diffusion was a more sensitive measure of age mediated changes in disk tissues. Strong differences in the association of MR parameters with age between the lumbar and thoracic suggest that mechanical environment effects tissue specific MR parameters' association with age. |
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