Carvacrol ameliorates behavioral disturbances and DNA damage in the brain of rats exposed to propiconazole |
| |
| Institution: | 1. Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt;2. Department of Animal Hygiene and Management, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt;1. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA;2. Department of Psychology, Auburn University, Auburn, AL, USA;1. Department of Physiology, Health Sciences Institute, Federal University of Bahia, 40110-100, Salvador, Bahia, Brazil;2. Life Sciences Department, Bahia State University, 41195-001, Salvador, Bahia, Brazil;1. Department of Neurosurgery, the First Affiliated Hospital, Medical School of Xi''an Jiaotong University, Xi''an, Shaanxi 710061, China;2. Library of the First Affiliated Hospital, Medical School of Xi''an Jiaotong University, Xi''an, Shaanxi 710061, China;3. Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi''an, Shaanxi 710032, China;4. Department of Neurosurgery, the Dingxi First People''s Hospital, Dingxi, Gansu 743000, China;5. Department of Neurosurgery, the Northwest Civil Aviation Hospital, Xi''an, Shaanxi 710061, China;1. State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, 211198, China;2. School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005, China;3. Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing, 100875, China;4. Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA;1. Department of Medical Science, Chungnam National University School of Medicine, Daejeon, South Korea;2. Department of Biochemistry, Chungnam National University School of Medicine, Daejeon, South Korea;3. Department of Anesthesia and Pain Medicine, Chungnam National University School of Medicine, Daejeon, South Korea;4. Department of Anesthesia and Pain Medicine, Chungnam National University Hospital, Daejeon, South Korea;5. Center for Electron Microscopy Research, Korea Basic Science Institute, Cheongju, Chungcheongbukdo, South Korea |
| |
| Abstract: | Propiconazole (PCZ) is an ergosterol biosynthesis inhibiting fungicide. Carvacrol (CAR) is a monoterpenoid phenol that has various beneficial health effects. The current research was designed to study the impact of PCZ on the behavior of rats and its ability to induce DNA damage in neurons as well as to clarify the ameliorative effect of CAR against these toxic impacts. Sixty Sprague-Dawley rats were randomly and equally divided into 4 experimental groups and treated daily by oral gavage for 2 months as follows: Group 1 (control); group 2 treated with PCZ (75 mg/kg); group 3 treated with CAR (50 mg/kg) and group 4 treated with both PCZ and CAR. Behavioral tests demonstrated that exposure to PCZ had a deleterious effect on psychological, motor and cognitive neural functions. Additionally, antioxidant enzyme activities, SOD and GSH-Px, were declined in brain tissue following exposure to PCZ. Moreover, comet assay revealed a high percent of DNA damage in the brain of rats exposed to PCZ. On the other hand, CAR administration ameliorated the harmful effects induced by PCZ through a protective mechanism that involved the improvement of neural functions and attenuation of oxidative stress and DNA damage. |
| |
| Keywords: | Triazole fungicides Oregano Open field test Object recognition test Antioxidants Comet assay |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
