| 富含半胱氨酸蛋白61在结直肠癌中的应用 |
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| 引用本文： | 张华,李永兴,谢叶丽,项明洁.富含半胱氨酸蛋白61在结直肠癌中的应用[J].标记免疫分析与临床,2019,26(3):385-388. |
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| 作者姓名： | 张华 李永兴 谢叶丽 项明洁 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院卢湾分院放免检验科,上海,200020;同济大学附属杨浦医院检验科,上海,200090 |
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| 摘 要： | 目的通过测定结直肠癌(colorectal cancer,CRC)患者血清富含半胱氨酸蛋白61(cysteine-rich Protein 61,Cyr61)水平,分析其用于结直肠癌诊断和病理评估的价值。方法用ELISA方法检测血清Cyr61浓度,再用ROC曲线计算最佳灵敏度和特异性,比较Cyr61在诊断结直肠癌的效果;分析Cyr61水平与结直肠癌TNM分期及淋巴结转移的关系,探究血清Cyr61水平与结直肠癌临床病理分期的关系。结果 CRC患者的血清Cyr61水平明显高于健康对照组(P<0.05),血清Cyr61、CEA和CA19-9检测对诊断结直肠癌的灵敏度分别为70.2%、48.2%和48.9%,Ⅲ-Ⅳ期血清Cyr61表达高于Ⅰ-Ⅱ期,有淋巴结转移的血清Cyr61表达高于无淋巴结转移。结论血清Cyr61水平可作为CRC诊断的潜在标志物,且与肿瘤分期和淋巴结转移有关,血清Cyr61水平对结直肠癌的监测有重要意义。
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| 关 键 词： | 结直肠癌 Cyr61 血清肿瘤标志物 |
The Application of Cysteine-rich Protein 61 in the Diagnosis of Colorectal Cancer |
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| ZHANG Hua,LI Yong-xing,XIE Ye-li,XIANG Ming-jie.The Application of Cysteine-rich Protein 61 in the Diagnosis of Colorectal Cancer[J].Labeled Immunoassays and Clinical Medicine,2019,26(3):385-388. |
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| Authors: | ZHANG Hua LI Yong-xing XIE Ye-li XIANG Ming-jie |
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| Institution: | (Department of RIA and Clinical Laboratory,Luwan Branch of Ruijin Hospital,Shanghai Jiaotong University Schoolof Medicine,Shanghai 200020,China;Yangpu Hospital,Tongji University,Shanghai 200090,China) |
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| Abstract: | ZHANG Hua;LI Yong-xing;XIE Ye-li;XIANG Ming-jie(Department of RIA and Clinical Laboratory,Luwan Branch of Ruijin Hospital,Shanghai Jiaotong University Schoolof Medicine,Shanghai 200020,China;Yangpu Hospital,Tongji University,Shanghai 200090,China) |
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| Keywords: | Colorectal cancer Cyr61 Serum tumor marker |
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