人工肝支持系统治疗重型肝炎130例报道

目的探讨人工肝支持系统治疗重型肝炎的疗效,治疗时机及不良反应的发生率。方法252例重型肝炎患者随机分为治疗组130例,对照组122例。两组在综合护肝治疗的基础上,治疗组同时给予人工肝支持系统(ALSS)治疗,观察不同病期的治疗效果及不良反应。结果治疗组重型肝炎早、中、晚期有效率分别为97.87%、82.00%、30.30%,总有效率72.30%;对照组分别为69.64%、53.66%、12.00%,总有效率52.46%,两组比较差异有显著性(P<0.001)。治疗组人工肝支持系统治疗670例次,发生不良反应62例次,不良反应发生率9.25%。结论人工肝支持系统治疗重型肝炎安全有效,尤以早、中期效果最好。

A report of 130 severe hepatitis cases treated with artificial liver support system

Objective To evaluate the therapeutic effect, the treatment time, and the incidence of side effect of artificial liver support system (ALSS) the treating severe hepatitis. Methods Two hundred and fifty-two patients with severe hepatitis were randomly divided into the treatment group (130 cases) and the control group (122 cases). Comprehensive liver-protecting therapy was given to all patients in two groups. Additionally, ALSS was given to the treatment group simultaneously. The therapeutic effects and side effects of ALSS in patients of different stages were observed. Results The general effective rate of the treatment group was 72.30%.And the effective rate for early, middle and late stage patients in the treatment group were 97.87%, 82.00%, and 30.30% respectively. The general effective rate for the control group was 52.46%. And the effective rate for early, middle and late stage patients in the control group were 69.64%, 53.66%, and 12.00% respectively. There was significant difference between these two groups in effective rates (P < 0.001). Six hundred and seventy casetimes of ALSS was used in the treatment group. The side effects of ALSS occurred 62 case-times. And the incidence of side effects was 9.25%. Conclusion ALSS is an effective and safe way for the treatment of patients with severe hepatitis, especially for patients in early or middle stage.