| 早期煤工尘肺患者CT肺纤维化评分与肺表面活性蛋白表达分析 |
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| 引用本文： | 韩文慧,邢景才,任侯卯,王海椒,杨丽娟,田红霞,张可英,陈卫红. 早期煤工尘肺患者CT肺纤维化评分与肺表面活性蛋白表达分析[J]. 公共卫生与预防医学, 2009, 20(1): 4-7 |
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| 作者姓名： | 韩文慧 邢景才 任侯卯 王海椒 杨丽娟 田红霞 张可英 陈卫红 |
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| 作者单位： | 西山煤电集团总医院,太原,030053;华中科技大学同济医学院公共卫生学院劳动卫生与环境卫生系,环境与健康教育部重点实验室 |
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| 基金项目： | 国家自然科学基金资助项目(30571553) |
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| 摘 要： | 目的探讨64排螺旋CT对早期煤工尘肺纤维化定量评分的实用价值。方法用特殊容积软件，对19例0＋期煤工尘肺患者的64排螺旋CT胸部平扫图像，进行肺正常密度容积百分比评分，并以肺正常密度容积百分比60％为界分为轻症和重症两组；采集两组患者全肺灌洗治疗后的肺灌洗回收液，用ELISA法检测全肺灌洗回收液中肺泡表面活性蛋白A和D（SP-A、SP-D）含量。结果64排螺旋CT肺正常密度容积百分比与全肺灌洗回收液中SP—D表达水平呈高度显著负相关（r=-0．801，P〈0．01）。CT重症组平均累积接尘量（743．2±384．5）mg／m3·y及残气占肺总量百分比（36．5％）均明显高于轻症组（280．7±271．3）mg／m3·y和30．3％，差异有极显著性统计学意义（P〈0．01）。结论64排螺旋CT肺正常密度容积百分比测定能对早期煤工尘肺患者的肺纤维化程度进行客观和精确的评估；CT肺纤维化评分与患者全肺灌洗液标志物SP-D表达水平密切相关。
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| 关 键 词： | 尘肺 全肺灌洗液 多排螺旋CT 肺表面活性蛋白-D |
Lung fibrosis C- score and expression of surfactant protein-D in early stage of coal worker pneumoconiosis |
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| HAN Wen-hui,XING Jing-cai,REN Hou-mao,YANG Li-juan,TIAN Hong-xia,ZHANG Ke-yin,WANG Hai-jiao,CHEN Wei-hong. Lung fibrosis C- score and expression of surfactant protein-D in early stage of coal worker pneumoconiosis[J]. Journal of Public Health and Preventive Medicine, 2009, 20(1): 4-7 |
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| Authors: | HAN Wen-hui XING Jing-cai REN Hou-mao YANG Li-juan TIAN Hong-xia ZHANG Ke-yin WANG Hai-jiao CHEN Wei-hong |
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| Affiliation: | HAN Wen-hui,XING Jing-cai,REN Hou-mao,YANG Li-juan,TIAN Hong-xia,ZHANG Ke-yin.Central hospital of Xishan Coal & Power Group Ltd 030053,China,WANG Hai-jiao,CHEN Wei-hong.MOE Key Lab of Environmental , Health,School of Public Health,Tongji Medical College,Huazhong University of Science & Technology,Wuhan 430030 |
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| Abstract: | Objective To evaluate the clinical value of lung fibrosis score by 64-slice spiral CT as a method to diagnose coal workers' pneumoconiosis in early stage.Methods The 64-slice spiral CT routine scan was used on 19(stage 0+) patients with coal workers' pneumoconiosis.The tomography images were quantitatively scored with special categorical volume software,the result of which expressed as volume percentage of lung parenchyma with normal density.According to the CT score,the patients whose normal lung parenchym... |
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| Keywords: | Pneumoconiosis Lung lavage fluid Multi-slice spiral CT Lung surfactant protein-D |
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