The utility of SARS‐CoV‐2 nucleocapsid protein in laboratory diagnosis |
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Authors: | Xinwei Li Mengyuan Xiong Qiaoling Deng Xiaobing Guo Yirong Li |
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Institution: | 1. Class 11, Grade 2018, Medical School of Zhengzhou University, Zhengzhou China ; 2. Department of Laboratory Medicine, Zhongnan Hospital, Wuhan University, Wuhan China ; 3. Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou China |
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Abstract: | BackgroundThe Coronavirus Disease 2019 (COVID‐19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), which has now become a global pandemic owing to its high transmissibility. The SARS‐CoV‐2 nucleocapsid protein tests are playing an important role in screening and diagnosing patients with COVID‐19, and studies about the utility of SARS‐CoV‐2 nucleocapsid protein tests are increasing now.MethodsIn this review, all the relevant original studies were assessed by searching in electronic databases including Scopus, Pubmed, Embase, and Web of Science. “SARS‐CoV‐2”, “COVID‐19”, “nucleocapsid protein”, and “antigen detection” were used as keywords.ResultsIn this review, we summarized the utility of SARS‐CoV‐2 nucleocapsid protein in laboratory diagnosis. Among the representative researches, this review analyzed, the sensitivity of SARS‐CoV‐2 nucleocapsid protein detection varies from 13% to 87.9%, while the specificity could almost reach 100% in most studies. As a matter of fact, the sensitivity is around 50% and could be higher or lower due to the influential factors.ConclusionIt is well suggested that SARS‐CoV‐2 nucleocapsid protein is a convenient method with a short turnaround time of about half an hour, and the presence of N antigen is positively related to viral transmissibility, indicating that SARS‐CoV‐2 N protein immunoassays contribute to finding out those infected people rapidly and segregating them from the uninfected people. |
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Keywords: | antigen detection COVID‐ 19 laboratory diagnosis nucleocapsid protein SARS‐ CoV‐ 2 |
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