| 柑橘类黄酮诺必擂停的抗肿瘤作用及其机制 |
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| 引用本文： | 成美英,张洪泉. 柑橘类黄酮诺必擂停的抗肿瘤作用及其机制[J]. 药学进展, 2005, 29(8): 355-359 |
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| 作者姓名： | 成美英 张洪泉 |
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| 作者单位： | 扬州大学医药研究所,江苏,扬州,225001 |
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| 摘 要： | 综述柑橘类黄酮诺必擂停(NOB)的抗肿瘤药理作用及其机制。NOB是从柑橘类果实中提取的一种具有抗癌作用的生物活性成分,能通过多重机制有效抑制多种肿瘤细胞的增殖,但对正常人体细胞增殖的影响小,且与其他抗癌药有协同作用,可逆转肿瘤的多药耐药性,有望成为一种新型肿瘤防治药物。
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| 关 键 词： | 诺必擂停 抗肿瘤 药理作用 作用机制 协同作用 多药耐药性 |
| 文章编号： | 1001-5094（2005）08-0355-05 |
| 收稿时间： | 2005-01-22 |
| 修稿时间： | 2005-01-22 |
Anticancer Activity and Mechanism of Action of Nobiletin, a Citrus Polymethoxy Flavonoid |
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| CHENG Mei-ying,ZHANG Hong-quan. Anticancer Activity and Mechanism of Action of Nobiletin, a Citrus Polymethoxy Flavonoid[J]. Progress in Pharmaceutical Sciences, 2005, 29(8): 355-359 |
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| Authors: | CHENG Mei-ying ZHANG Hong-quan |
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| Abstract: | The anticancer activity and mechanism of action of nobiletin(NOB), a Citrus polymethoxy flavoniod, were reviewed. NOB, an active constituent extracted from Citrus reticulata Blanco, can inhibit proliferation of many tumors in multiple mechanisms, but it affects normal human cells a little. Besides it has synergism with other anticancer drugs and reverses multidrug resistance of tumor. It could be of future therapeutic value. |
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| Keywords: | Nobiletin Antitumor Pharmocological action Mechanism of action Synergism Multidrug resistance |
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