| 地骨皮提取液对2型糖尿病大鼠肾脏COX一2表达的影响 |
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| 引用本文： | 杨珺.地骨皮提取液对2型糖尿病大鼠肾脏COX一2表达的影响[J].浙江中西医结合杂志,2011,21(7):461-462,507. |
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| 作者姓名： | 杨珺 |
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| 作者单位： | 浙江省中医院,杭州,310006 |
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| 摘 要： | 目的：观察地骨皮醇提取液对2型糖尿病大鼠肾脏COX一2表达的影响，探讨其对糖尿病肾病大鼠肾脏保护作用的机制。方法：SD大鼠125只，随机抽取10只为正常对照组。以STZ加高脂饲料饲养3周复制2型糖尿病肥胖大鼠模型，随机分为模型组、罗格列酮组、地骨皮醇提低剂量组、地骨皮醇提高剂量组，每组10只。模型组和正常组给予生理盐水，各实验组分别给予相应药物灌胃，治疗7周后免疫组化法检测’净脏COX一2表达。结果：罗格列酮组和地骨皮醇提组COX一2表达与模型组比较明显改善，差异均有统计学意义（P〈0．01），但与正常对照组之间仍有明显差异（P＜0．01）。地骨皮醇提高剂量组与罗格列酮组比较差异无统计学意义（侈0．05）。结论：地骨皮醇提取液可以降低2型糖尿痛肥胖大鼠肾脏COX一2的表达，其中高剂量组优于低剂量组，与罗格列酮组疗效相当．
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| 关 键 词： | 地骨皮 2型糖尿病 COX一2 肥胖大鼠 |
Effect of Digupi Ethanol Extract on the Renal Expression of Cox-2 in Type 2 Diabetic Rats |
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| YANG Jun.Effect of Digupi Ethanol Extract on the Renal Expression of Cox-2 in Type 2 Diabetic Rats[J].Zhejiang Journal of Integrated Traditional Chinese and Western Medicine,2011,21(7):461-462,507. |
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| Authors: | YANG Jun |
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| Institution: | YANG Jun.Zhejiang Hospital of Traditional Chinese Medicine,Hangzhou(310006),China |
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| Abstract: | Objective:To observe the effect of Digupi extract on renal expression of cox-2 in rats with type 2 diabetic mellitus(DM),and to reveal the underlying mechanism.Methods:Sprague Dawley rats were given high fat diet for 3 weeks to establish type 2 DM obesity.Obese rats were randomly divided into model group,rosiglitazone group,Digupi ethanol extract low dose group(low Digupi group),and Digupi ethanol extract high dose group(high Digupi group),10 in each.Other 10 rats served as normal control.The model and norm... |
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| Keywords: | COX-2 |
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