| 氯氮平的诱变研究 |
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| 引用本文： | 江三多,夏镇夷,张兆麟,沈惠觉.氯氮平的诱变研究[J].中国新药与临床杂志,1990(6). |
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| 作者姓名： | 江三多 夏镇夷 张兆麟 沈惠觉 |
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| 作者单位： | 上海市精神卫生研究所 上海200030
(江三多，夏镇夷)，苏州市广济医院 苏州215000
(张兆麟)，苏州市广济医院 苏州215000(沈惠觉) |
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| 摘 要： | 本文应用姐妹染色单体互换(SCE)技术和酵母菌(Saccharomyces cerevisiae,YEPD8534-8c)的药物诱变性检测法,研究氯氮平的诱变效应。结果没有显示氯氮平对核基因和细胞质基因的任何诱变效应。提示氯氮平从诱变角度看是安全的。
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| 关 键 词： | 氯氮平 姐妹染色单体交换 诱变性试验 酿酒酵母菌 |
A study of mutagenicity on clozapine |
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| JIANG San-Duo,XIA Zhen-Yi.A study of mutagenicity on clozapine[J].Chinese Journal of New Drugs and Clinical Remedies,1990(6). |
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| Authors: | JIANG San-Duo XIA Zhen-Yi |
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| Abstract: | A study of mutagenic effects of clozapine with the sister chromatid exchange techniques and the mutagenicity assay of drugs on Saccharomyces ccrcvisiae (YEPD 8534~8c)was performed. The results did not show any mutagenic effect of clozapine in both nuclear and cytoplasmic genes. It suggests that clozapine is sate in mutagenic aspect. |
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| Keywords: | clozapine sister chromatid exchange mutagenicity tests Saccharomyces cerevisiae |
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