| 盐酸青藤碱大鼠肠吸收实验研究 |
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| 引用本文： | 张丽锋,王锐利,张淑秋.盐酸青藤碱大鼠肠吸收实验研究[J].中国药学杂志,2007,42(20):1556-1557. |
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| 作者姓名： | 张丽锋 王锐利 张淑秋 |
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| 作者单位： | 山西医科大学药学院临床药学教研室,太原,030001 |
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| 基金项目： | 山西省留学回国人员科研项目 |
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| 摘 要： | 目的研究盐酸青藤碱在大鼠不同肠段的吸收特性,为其剂型设计提供理论依据。方法以酚红为标示物,采用在体单灌流法进行肠吸收实验研究,高效液相色谱法测定灌流液中盐酸青藤碱和酚红的浓度,计算吸收性能参数。结果盐酸青藤碱在十二指肠、空肠、回肠、结肠的有效渗透系数(Peff)分别为0.65±0.15,0.54±0.26,0.45±0.14,0.28±0.12(×10-4cm·s-1),表明该药在大鼠各肠段均有较好的吸收。结论盐酸青藤碱适于制成日服1次的缓控释制剂。
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| 关 键 词： | 盐酸青藤碱 在体单灌流模型 吸收 高效液相色谱法 |
| 文章编号： | 1001-2494（2007）20-1556-03 |
| 收稿时间： | 2006-07-19; |
| 修稿时间： | 2006-07-19 |
Study on Absorption of Sinomenine Hydrochloride in Rat Intestines |
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| ZHANG Li-feng,WANG Rui-li,ZHANG Shu-qiu.Study on Absorption of Sinomenine Hydrochloride in Rat Intestines[J].Chinese Pharmaceutical Journal,2007,42(20):1556-1557. |
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| Authors: | ZHANG Li-feng WANG Rui-li ZHANG Shu-qiu |
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| Institution: | Department of Clinical Pharmacy, Pharmacy College, Shanxi Medical Uni versify, Taiyuan 030001, China |
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| Abstract: | OBJECTIVE To study the absorption characters of sinomenine hydrochloride in various intestine segments.METHODS Phenol red was used as the indicator.The intestine absorption characters of sinomenine hydrochloride were detected by the in situ single-pass intestine perfusion method.The concentrations of phenol red and sinomenine hydrochloride in the perfusate were determined by HPLC.RESULTS The effective permeability(Peff,10-4 cm·s-1) of sinomenine hydrochloride in duodenum,jejunum,ileum and colon was 0.65±0.15,0.54±0.26,0.45±0.14 and 0.28±0.12,respectively.CONCLUSION Sinomenine hydrochloride was suitable for the sustained or controlled release preparations for once daily. |
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| Keywords: | sinomemine hydrochloride in situ single-pass perfusion absorption HPLC |
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