Selectivity of cerebral vasodilators on basilar arteries |
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| Authors: | I Takayanagi K Koike N Miyake R Sato K Yamada |
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| Affiliation: | 1. Department of Pharmacology, Physiology and Neuroscience, Rutgers University – New Jersey Medical School, Newark, NJ, USA;2. Division of Infectious Disease, Department of Medicine, and the Ruy V. Lourenco Center for the Study of Emerging and Reemerging Pathogens, Rutgers University – New Jersey Medical School, Newark, NJ, USA;1. Swiss Tropical and Public Health Institute, Basel, Switzerland;2. University of Basel, Basel, Switzerland;3. National Institute of Public Health, Vientiane, Lao Democratic People''s Republic;4. University of Health Sciences, Faculty of Medicine, Vientiane, Lao Democratic People''s Republic;1. School of Biological Sciences and Institute for Global Food Security, Queen''s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, BT9 7BL, UK;2. School of Pharmacy and Biomolecular Sciences, University of Brighton, Huxley Building, Lewes Road, Brighton, BN2 4GJ, UK;1. Center for Drug Discovery, RTI International, 3040 Cornwallis Rd, Research Triangle Park, NC, 27709, USA;2. Department of Nutrition, University of North Carolina at Chapel Hill, Nutrition Research Institute, 500 Laureate Way, Kannapolis, NC, 28081, USA;1. Laboratory of Analytical Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan;2. School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women''s University, 11-68 Koshien-Kyubancho, Nishinomiya, Hyogo 663-8179, Japan;3. Laboratory of Synthetic Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Yamadaoka 1-6, Suita, Osaka 565-0871, Japan;4. Compound Library Screening Center, Graduate School of Pharmaceutical Sciences, Osaka University, Yamadaoka 1-6, Suita, Osaka 565-0871, Japan;1. Department of Pathophysiology and Host Defense, The Research Institute of Tuberculosis – Japan Anti-Tuberculosis Association, 3-1-24 Matsuyama, Kiyose, Tokyo 204-8533, Japan;2. NCGM-BMH Medical Collaboration Center, Hanoi, Vietnam;3. Department of Biochemistry, Hematology and Blood Transfusion, Hanoi Lung Hospital, Hanoi, Vietnam;4. Hanoi Department of Health, Hanoi, Vietnam;5. Hanoi Lung Hospital, Hanoi, Vietnam;6. National Center for Global Health and Medicine, Tokyo, Japan;7. NHO Tokyo National Hospital, Tokyo, Japan;8. Bureau of International Medical Cooperation, National Center for Global Health and Medicine, Tokyo, Japan;9. Research Institute of Immune Diagnosis, Tokyo, Japan |
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| Abstract: | Ca-antagonistic activities of cerebral vasodilators, nicardipine and 1-(3,4-dimethoxyphenyl)-2-(4-diphenylmethylpiperazinyl)ethanol dihydrochloride (NC-1100) were tested on basilar and renal arteries, thoracic aorta and portal vein of rabbit, and rat vas deferens. Both the cerebral vasodilators used herein had a selectivity to basilar arteries. The selectivity to the basilar arteries is considered to be one of the factors in deciding the pharmacological property of the cerebral vasodilators. |
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