Effects of Quyu Xiaoban Capsule(祛瘀消斑胶囊) on Vascular Endothelial Function in Patients with Atherosclerosis |
| |
作者姓名: | Liu YF Zhao YX Yu HM |
| |
作者单位: | [1]Department of Diagnosis, School of Medicine, Shandong University, Jinan (250012) [2]Department of Traditional Chinese Medicine, Qilu Hospital, Shandong University |
| |
基金项目: | Supported by the 9th 5-year Key Project of Shandong Provincial Ministry of Health (No. 9711) |
| |
摘 要: | Objective: To evaluate the therapeutic effects of Quyu Xiaoban Capsule (祛瘀消斑胶囊 ,QYXBC) on endothelial dependent vascular relaxation (EDVR) function in patients with atherosclerosis (AS)with ultrasonic technique. Methods: Tested were the endothelial function and blood lipids of 42 patients with AS in the treated group and 30 healthy volunteers in the control group. And re-examination of these parameters was carried out on the AS patients after they had been treated with QYXBC for 10 months. Results: Before treatment, the reactive hyperemia induced changes in artery diameter in the treated group was significantly lower than that in the control group (P<0.01), while insignificant difference was found between the two groups in response to nitroglycerin. In the treated group after treatment, with D%-R improved significantly (P<0.01), total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C)decreased by 16.3%, 5.6%, 10.2% respectively and high-density lipoprotein cholesterol (HDL-C) increased by 7.5%. EDVR was correlated negatively with the serum TC, LDL-C concentrations and the baseline brachial diameter (D0) (r = -0.41, -0.66, -0.59, respectively, all P<0.01), but correlated positively with HDL-C (r = 0.62, P<0.05). The ameliorative extent of EDVR was correlated positively to the decreased magnitude of TC and LDL-C concentrations ( r = 0.67,0.59, both P<0.01 ). Conclusion: QYXBC can lower the level of blood lipids and improve significantly EDVR function.
|
收稿时间: | 10 28 2005 12:00AM |
Effects of Quyu Xiaoban Capsule on vascular endothelial function in patients with atherosclerosis |
| |
Authors: | Liu Yun-fang Zhao Yu-xia Yu Hui-ming |
| |
Abstract: | Objective: To evaluate the therapeutic effects of Quyu Xiaoban Capsule, (QYXBC) on endothelial dependent vascular relaxation (EDVR)
function in patients with atherosclerosis (AS) with ultrasonic technique.Methods: Tested were the endothelial function and blood lipids of 42 patients with AS in the treated group and 30 healthy volunteers
in the control group. And re-examination of these parameters was carried out on the AS patients after they had been treated
with QYXBC for 10 months.Results: Before treatment, the reactive hyperemia induced changes in artery diameter in the treated group was significantly lower
than that in the control group (P < 0.01), while insignificant difference was found between the two groups in response to nitroglycerin. In the treated group
after treatment, with D%-R improved significantly (P < 0.01), total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) decreased by 16.3%, 5.6%,
10.2% respectively and high-density lipoprotein cholesterol (HDL-C) increased by 7.5%. EDVR was correlated negatively with
the serum TC, LDL-C concentrations and the baseline brachial diameter (D0 (r = -0.41, -0.66, -0.59, respectively, allP < 0.01), but correlated positively with HDL-C (r = 0.62,P < 0.05). The ameliorative extent of EDVR was correlated positively to the decreased magnitude of TC and LDL-C concentrations
(r = 0.67,0.59, bothP < 0.01).Conclusion: QYXBC can lower the level of blood lipids and improve significantly EDVR function.
Supported by the 9th 5-year Key Project of Shandong Provincial Ministry of Health (No. 9711) |
| |
Keywords: | Quyu Xiaoban Capsule atherosclerosis endothelial function |
本文献已被 CNKI 维普 万方数据 PubMed SpringerLink 等数据库收录! |
|