中年自然人颈动脉粥样硬化斑块与血清hs-CRP、HCY水平的相关研究

目的:探讨中年自然人颈动脉粥样硬化斑块形成与血清同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)的相互关系。方法:对205名中年自然人采用彩色多普勒超声诊断仪测定其颈动脉粥样硬化斑块是否存在,分成斑块组(32例)和非斑块组(173例)。同时检测血清Hcy、hs-CRP及其他相关指标。结果:⑴单因素分析仅年龄、Hcy、hs-CRP在斑块组和非斑块组之间有显著差别(P<0.05),多因素分析中年自然人的年龄、Hcy、hs-CRP是颈动脉斑块形成的危险因素(P<0.1,β>0,OR>1)(2)采用以年龄为协变量的协方差分析对中年自然人血清hs-CRP、Hcy进行分析比较,中年自然人的血清hs-CRP、Hcy差异主要与颈动脉的硬化斑块形成有关(P<0.05)。结论:中年自然人的血清Hcy、hs-CRP水平与颈动脉粥样硬化斑块形成密切相关,是比较重要的危险因素,早期常规筛选意义重大。

Relationship of Carotid Atherosclerosis with Serum hs-CRP and Hcy in Middle-aged Individual

Objective:To study whether the formation of carotid atherosclerotic plaque in middle-aged individual is associated with the level of serum homocysteine(Hcv) or high sensitive C-reactive protein(hs-CRP).Methods: After measured for carotid atherosclerotic plaque by color Doppler ultrasonic diagnostic apparatus,205middle-aged individuals were divided into two groups,plaque group(n=32) and non-plaque group(n=173).The level of serum Hcv,hsCRP and other related indicators were detected simultaneously.Results:(1) Using one factors analysis,it showed that the significant difference between plaque group and non-plaque is only in age,Hcy and hs-CRP P<0.05).Many factors analysis showed that the age,Hcy and hs-CRP is carotid plaques form risk factors in the middle-aged individuals.(2) To the age for the variables of the covariance analysis of covariance middle-aged individual of serum Hcy、hs-CRP carries on the analysis comparison,middle-aged individual Hcy、hs-CRP serum main differences with carotid atherosclerosis of which involved.Conclusion: The level of serum Hcv and hs-CRP is an important risk factor for the formation of plaque in carotid atherosclerosis in middle-aged individuals and is a potential indicate in early diagnosis.