氯氮平、利培酮与齐拉西酮对精神分裂症患者体重及血糖的影响研究

目的探讨氯氮平、利培酮、齐拉西酮三种抗精神病药物对精神分裂症患者体重及血糖的影响。方法将190例精神分裂症患者随机分成氯氮平、利培酮、齐拉西酮三组,分别给予单药治疗6个月。于治疗前、及治疗第1、2、3、6个月末监测患者体重及空腹血糖。结果治疗2个月后,氯氮平组、利培酮组体重较治疗前增加,差异具有统计学意义(P<0.05),治疗3个月后,氯氮平组、利培酮组血糖较治疗前增加,差异具有统计学意义(P<0.05),齐拉西酮组治疗前后体重和血糖差异无显著性(P>0.05)。结论氯氮平、利培酮对患者的体重及血糖均有影响,而齐拉西酮的影响不显著。

Comparative of effects of clozapine,risperidone and ziprasidone on body weight and blood glucose

Objective To investigate the effects of clozapine,risperidone and ziprasidone on body weight and blood glucose of patients with schizophrenia.Methods A total of 190 patients who met the criteria of CCMD-3 for schizophrenia were assigned to clozapine group,risperidone group and ziprasidone group.Using single drug for 6 months.Body weight and fasting plasma glucose were measured before and 1、2、3、6 months after drug administration.Results After 2 months treatment,body weight in clozapine group and risperidone group were highter than before(P<0.05).After 3 months treatment,blood glucose in clozapine group and risperidone group were highter than berore(P<0.05).But in ziprasidone group,we didn’t find the differences between before and after treatment(P>0.05).Conclusions Clozapine and Risperidone can effect body weight and blood glucose of patients with schizophrenia.Ziprasidone has no effects on body weight and blood glucose.