盐酸氯普鲁卡因用于连续硬膜外麻醉的临床观察

目的:观察3%盐酸氯普鲁卡因在连续硬膜外麻醉中的有效性和安全性。方法:60例在L2～3间隙连续硬膜外麻醉下行腹部及以下手术患者随机分为利多卡因组(对照组,n=30)和盐酸氯普鲁卡因组(实验组,n=30),分别注入2%利多卡因和3%盐酸氯普鲁卡因,术中观察心率(HR)、血压(BP)、呼吸频率(R)、脉搏血氧饱和度(SpO2)的变化,记录麻醉后痛觉消失时间、运动阻滞时间、痛觉恢复时间、运动恢复时间、感觉阻滞平面上界、麻醉质量评分及有无不良反应。结果:两组麻醉前后HR、BP、R、SpO2变化一致,组间比较无显著差异。实验组的痛觉消失时间、运动阻滞时间、痛觉恢复时间、运动恢复时间与对照组比较,差异具有显著性(P<0.05)。两组感觉阻滞平面相当,差异无显著性。两组麻醉质量0分加1分所占例数的百分比分别为90%和93%。麻醉效果均满意。两组患者均无不良反应。结论:3%盐酸氯普鲁卡因起效快、阻滞效果好、恢复快、无明显不良反应,能安全用于连续硬膜外麻醉。

The Effective Observation of Hydrochloroprocaine in Continuous Epidural Anesthesia

Objective:To investigate the efficacy and safety of 3%chloroprocaine hydrochloride in continuous epidural anesthesia.Methods:60 patients undergoing abdominal or the following surgery in continuous epidural anesthesia were randomly divided into two:lidocaine group(control group,n=30) and chloroprocaine hydrochloride group(experimental group,n=30),which were individually injected into 2% lidocaine and 3%chloroprocaine hydrochloride,The change of heart rate(HR),blood pressure(Bp),respiratory rate(R),oxygen saturation(SpO2) was observed and recorded;The pain disappeared time,motor block time,pain recovery time,sports recovery time,sense block plane ascending boundary,anesthesia quality grade,having or having not adverse reaction after anesthesia were determined.Results:The change of HR,BP,R,SpO2of the two groups was consistent and the two groups showed no significant difference before and after anesthesia;The pain disappearance time,motor block time,pain recovery time,exercise recovery time of the experimental group compared with the control group,the difference was significant(P<0.05),with statistical significance;Two groups had almost the same sense block plane,the difference was not significant;Anesthesia effect was both satisfied;Two groups of patients had both no adverse reactions.Conclusion:3%chloroprocaine hydrochloride can be safe for continuous epidural anesthesia because of fast onset of action,blocking effectively,quick recovery,no significant adverse reactions,.