| 硼替佐米对淋巴瘤细胞株体外药物敏感性及临床意义的研究 |
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| 引用本文： | 陈新峰,张明智,张旭东,岳光星,曹玲. 硼替佐米对淋巴瘤细胞株体外药物敏感性及临床意义的研究[J]. 医药论坛杂志, 2012, 0(4): 22-24 |
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| 作者姓名： | 陈新峰 张明智 张旭东 岳光星 曹玲 |
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| 作者单位： | 郑州大学第一附属医院肿瘤科 |
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| 摘 要： | 目的研究以7种人非霍奇金淋巴瘤(NHL)细胞株为实验对象,以细胞抑制率、半数抑制浓度(IC50)为指标,研究硼替佐米(Bortezomib,BZM)对7种淋巴瘤细胞株的体外敏感状况,从而为临床用药提供实验理论依据。方法 MTT法检测细胞抑制率,并计算半数抑制浓度IC50值。结果 7种淋巴瘤细胞株均对BZM敏感,但BZM对不同淋巴瘤细胞株的敏感性存在差异。结论 BZM对B细胞型、T细胞型淋巴瘤细胞株均敏感。
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| 关 键 词： | BZM 非霍奇淋巴瘤细胞株 MTT |
Sensitivity experiment of Bortezomib for lymphoma cell lines in vitro and its clinical significance |
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| CHEN Xin-feng,ZHANG Ming-zhi,ZHANG Xu-dong,YUE Guang-xing,CAO Ling. Sensitivity experiment of Bortezomib for lymphoma cell lines in vitro and its clinical significance[J]. Journal of Medical Forum, 2012, 0(4): 22-24 |
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| Authors: | CHEN Xin-feng ZHANG Ming-zhi ZHANG Xu-dong YUE Guang-xing CAO Ling |
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| Affiliation: | Department of oncology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China |
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| Abstract: | Objective To investigate the sensitivity of seven human non-Hodgkin’s lymphoma cell lines to bortezomib using in vitro MTT assay and provide theoretical basis for clinic.Methods The sensitivity of seven lymphoma cell lines to bortezomib was tested using in vitro MTT assay,and calculating the IC50.Results All the seven lymphoma cell lines were sensitive to bortezomib.The sensitivity of different cells to bortezomib varied.Conclusions Non-Hodgkin’s lymphoma involving B-cell type and T-cell type both sensitive to bortezomib. |
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| Keywords: | Bortezomib Non-Hodgkin’s lymphoma cell line MTT |
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