Ⅱ型糖尿病患者GAD-Ab和ICA联合检测及价值

对９１例Ⅱ型糖尿病患者及２８例正常人的血清，用ＥＬＬＳＡ法测定谷氨酸脱羧酶抗体（ＧＡＤ－Ａｂ）及胰岛细胞抗体（ＩＣＡ）。结果：Ⅱ型糖尿病人中抗体阳性率为３０．７６％，ＧＡＤ－Ａｂ阳性为１７．５０％，ＩＣＡ阳性为１５．３８％，双抗体阳性为２．１９％，对照组ＧＡＤ－Ａｂ和ＩＣＡ均为限性；抗体阳性各组体重指数（ＢＭＩ）较阴性组明显降低，且有显著性差异；小于４０岁患者抗体阳性率最高（６０％）；血清Ｃ肽水平

A Preliminary Study on Significance of Combined Determination of GAD-Ab and ICA in Type H Diabetes Mellitus

To evaluate the significance of glutamic acid decarboxylase antibody(GAD-Ab) and islet cell antibody(ICA)determination in type H diabetes mellitus . GAD-Ab and ICA of 91 patients with type Ⅱ diabetes mellitus were measured with ELISA and serum C - peptide was measured with radioimmunoassay. The autoantibody positive rate was highter than that of GAD-Ab (30.76% versus 17.50% P<0.01) and that of ICA (30.76% versus 15.38% P<0.01) in type Ⅱ diabetes mellitus. Body mass index(BMI) was lower in autoantibody positive groups than autoantibody negative group. The autoantibody positive rate was higher in ages< 40 group than those in ot,her ages groups. The serum C - peptide leve was double antibody positive group< GAD-Ab positive group< ICA positive group < autoantibody negative group. The combined determination of GAD-Ab and ICA may enhance the sensitivity of diagnosis of latent autoimmune diabetes mellitus in adults (LADA). It is an important line in diagnosis LADA that BMI is low and ages of onset of type Ⅱ diabetes mellitus is lower than 40 years old. The distroyed level of islet cell is related with the kinds and number of autoantibody.