利奈唑胺多药联合对患者血小板影响回顾性分析

目的：回顾性分析利奈唑胺与其他抗感染药物联合抗感染治疗期间,多药应用对患者血小板的影响。方法：以利奈唑胺应用起点及终点时间为主要筛选标准,筛选应用利奈唑胺时间〉7 d的患者共82例,分为4组：A=利奈唑胺;B=利奈唑胺＋抗细菌药;C=利奈唑胺＋抗细菌药＋抗真菌药;D=利奈唑胺＋抗真菌药。对各组血小板行统计分析,观察利奈唑胺对各组的影响。结果：用药时间对B组与C组血小板计数值的影响无显著性差异,但B组与C组应用利奈唑胺前血小板的计数值存在基线差异（P〈0.05）,其后各时间点血小板计数值也存在统计学差异（P〈0.05）,但各组血小板计数均在正常值范围。结论：在利奈唑胺多药应用过程中血小板计数虽有所降低,但该影响较小。

Retrospective analysis of the effect of linezolid combined with other antibiotics on patients' platelets counts

Objective:The effect of linezolid combined with other antibiotics on the prognosis and the platelets was retrospetively analysed.Methods: The main screen standard was the start and stop time points of linezolid therapy,82 patients who used linezolid for more than 7 days were involved in this study.Patients were divided into 4 groups: A=linezolid;B=linezolid+ antibacterial agents;C= linezolid+ antibacterial agents+ antifungal antibiotic;D= linezolid+ antifungal antibiotic.Statistics of the number of platelet were performed.Results:There were no significant difference in group B and C for the time of therapy(P>0.05).However,the baseline of platelet counts between group B and C was significantly different(P<0.05),and the platelet counts had a significant difference at different time points(P<0.05).Conclusion:Combined use of linezolid with other antibiotics could decrease the platelet counts,but the effect was not significant.