| TrkB在前列腺癌中的表达及临床意义 |
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| 引用本文： | 郭宏林,李建华,苏燕胜,王禾. TrkB在前列腺癌中的表达及临床意义[J]. 西北国防医学杂志, 2011, 32(1): 21-23 |
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| 作者姓名： | 郭宏林 李建华 苏燕胜 王禾 |
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| 作者单位： | 解放军323医院泌尿外科,陕西,西安,710054 |
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| 摘 要： | 目的：研究TrkB在前列腺癌中的表达及临床意义。方法：利用免疫组化的方法研究TrkB在前列腺良性增生性病变组织与前列腺癌组织中的表达，分析TrkB的表达与肿瘤的病理分级之间的关系和TrkB的组织定位与前列腺癌进程之间的关系。结果：TrkB在前列腺癌细胞中高表达，其高表达趋势与前列腺癌的病理分级水平成正相关。TrkB在前列腺癌细胞上主要分布在细胞浆和细胞膜，但是在部分病例中发现TrkB具有非常特异和明确的核定位现象。结论：TrkB可能参与了前列腺癌的发生与发展的进程。
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| 关 键 词： | 前列腺癌 受体型酪氨酸激酶 TrkB |
Expression and clinical value of TrkB in the prostate cancer tissues |
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| Affiliation: | GUO Hong-lin,LI Jian-hua,SU Yan-sheng,et al.(323 Hospital,PLA,Xi’an 710054,China) |
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| Abstract: | Objective:To determine the expression and clinical value of TrkB in the prostate cancer tissues.Methods: Immunohistochemistry was performed to detect the expression of TrkB in the malignant tumor of prostate.The tissue of benign neoplasia was used as the control.Results:The expression of TrkB was higher in prostate cancer tissues than that in the benign neoplasia.And its expression trend was correlated with the malignant degree of the carcinoma.TrkB was mainly expressed on the cellular membrane and the cytoplasma.Conclusion:TrkB may involve in the program of prostate carcinogenesis. |
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| Keywords: | TrkB |
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