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| 盐酸尼卡地平缓释片的制备及释放度测定 | |
| 引用本文： | 林丽,郑俊民,云天英. 盐酸尼卡地平缓释片的制备及释放度测定[J]. 海南医学院学报, 2009, 15(6): 553-555 |
| 作者姓名： | 林丽 郑俊民 云天英 |
| 作者单位： | 1. 海南省卫生学校,海南,海口,570311 2. 沈阳药科大学,辽宁,沈阳,11000 3. 海南医学院附属医院,海南,海口,570102 |
| 摘 要： | 目的：研究确定盐酸尼卡地平缓释片的处方改进的可能性并进行体外释放度测定。方法：选用HPMC和泊洛沙姆作为缓释材料，采用试凑法（error and try）优选处方，并对最优处方进行释放度测定和体外释药拟合。结果：按最优处方制得的缓释片体外释放满足要求，释药行为符合1级动力学方程。结论：该缓释片处方设计合理，工艺重现性好，缓释效果好。 |
| 关 键 词： | 盐酸尼卡地平 迟效制剂 释放度测定 |
Prescription screening of Nicardipine hydrochloride sustained-release tablet and determination of release rate |
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| LIN Li,ZHENG Jun-min,YUN Tian-ying. Prescription screening of Nicardipine hydrochloride sustained-release tablet and determination of release rate[J]. Journal of Hainan Medical College, 2009, 15(6): 553-555 | |
| Authors: | LIN Li ZHENG Jun-min YUN Tian-ying |
| Affiliation: | LIN Li , ZHENG Jun-min , YUN Tian-ying ( 1. Health School in Hainan Province Haikou 570311 ; 2. Pharmaceutical University in Shenyang Shengyang 11000;3. Affitiated Hospital to Hainan Medical College Haikou 570102, China) |
| Abstract: | |
| Keywords: | Nicardipine hydrochloride Delayed action preparation Release determinaion |
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