Inhibiting effect of cytotoxic bromine-containing compounds from sponges (Aplysinidae) on Na-K-ATPase activity |
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Authors: | BA Gorshkov IA Gorshkova TN Makarieva VA Stonik |
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Institution: | Pacific Institute of Bioorganic Chemistry, Far East Science Centre, U.S.S.R. Academy of Science, Vladivostok, 690022, U.S.S.R. |
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Abstract: | —The bromine-containing compounds from sponges of the Aplysinidae family inhibit, in vitro, the Na+-K+-ATPase activity of the rat brain microsomal fraction. The extent of inhibition is dependent on concentration and chemical structure of the compounds. The substances containing the dienone fragment, such as 3,5-dibromo-1-hydroxy-4-oxo-2,5-cyclohexadien-1-acetamide (IV), 3,5-dibromo-1-acetoxy-4-oxo-2,5-cyclohexadien-1-acetonitrile (V) and 3,5-dibromo-1-hydroxy-4-oxo-2,5-cyclohexadien-1-ethylacetate (VI), are powerful inhibitors of Na+-K+-ATPase. |
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