Synthesis andin vitro antibacterial activity of quaternary ammonium cephalosporin derivatives bearing oxazolidinone moiety |
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Authors: | In Hwa Chung Choong Sup Kim Jae Hong Seo Bong Young Chung |
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Affiliation: | Biochemicals Research Center, Korea Institute of Science and Technology, Seoul. |
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Abstract: | Several oxazolidinones having amine moiety were prepared to form a quaternary ammonium salt with cephalosporin nucleus, and antibacterial activity of the quaternary ammonium cephalosporin derivatives bearing oxazolidinone moiety were examined particularly with expectation of dual activity. However, the cephalosporin-oxazolidinone compounds revealed rather weaker antibacterial activity in vitro than their parent oxazolidinone and cephalosporin without showing any characteristic activity as expected. |
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Keywords: | Oxazolidinone Quaternary ammonium cephalosporin Antibacterial activity |
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