| 余甘子抗疲劳、抗缺氧作用实验研究 |
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| 引用本文： | 崔炳权,;黄伟侨,;林元藻. 余甘子抗疲劳、抗缺氧作用实验研究[J]. 中药研究与信息, 2008, 0(6): 26-28 |
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| 作者姓名： | 崔炳权, 黄伟侨, 林元藻 |
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| 作者单位： | [1]广东药学院生物化学与分子生物学教研室,广东广州510006; [2]广州中山大学附属第一医院药学部,广东广州510080 |
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| 基金项目： | 2006年度广东药学院新药研发基金项目（xy06-01） |
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| 摘 要： | 目的：研究余甘子的抗疲劳、抗缺氧作用及其机制。方法：用不同剂量余甘子水提取物给正常小鼠连续灌胃30d，测定其负重游泳时间、抗缺氧时间；检测运动小鼠血中血红蛋白、乳酸、尿素氮、肝糖原含量及乳酸脱氢酶活性。结果：余甘子水提取物能延长小鼠的抗缺氧时间和游泳时间；显著提高小鼠血中血红蛋白含量、乳酸脱氢酶活性和肝糖原含量；显著降低血中乳酸、尿素氮含量。结论：余甘子具有显著的抗疲劳、抗缺氧功效。
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| 关 键 词： | 余甘子 抗疲劳 抗缺氧 |
Experimental Study of the Anti-Fatigue and Anti-Hypoxia Function of Phyllanthus emblica L. in Mice |
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| Affiliation: | Cui Bingquan , Huang Weiqiao, Lin Yuanzao (1. Department of Biochemistry and Molecular Biology, Guangdong Pharmaceutical University, Guangzhou Guangdong 510006, China; 2. Department of Pharmacy of the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou Guangdong 510080, China) |
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| Abstract: | Objective： To study the anti-fatigue and anti-hypoxia function of Phyllanthus emblica L. （PEL） and its possible mechanism. Methods： After mice were administrated intragastrically with different doses of PEL waterextracts for 30 days, swimming endurance test was conducted , anti-hypoxia time , physical and biochemical data were determined. Results： PEL water-extracts can prolong the duration of loaded-swimming and anti-hypoxia time of mice, significantly decrease the contents of blood lactic acid, blood urine nitrogen, and increase the contents of hepatic glycogen and blood hemoglobin, significantly improved the activity of blood lactate dehydrogenase （LDH）. Conclusion： PEL water-extracts can obviously increase the anti-fatigue and anti-hypoxia ability of mice. |
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| Keywords: | Phyllanthus emblica L. Anti-fatigue Anti-hypoxia |
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