C－myc癌基因在胃癌和癌前病变中的表达

本研究采用生物素标记的Ｃ－ｍｙｃ癌基因为探针，检测７０例胃部标本中Ｃ－ｍｙｃ癌基因ｍＲＮＡ的表达。结果发现Ｃ－ｍｙｃ癌基因的高表达在胃癌中占６０．４％，在胃的良性病变中占２７．２７％，两者之间有显著性差异（Ｐ＜０．０５）。在４８例胃癌的癌旁上皮中，Ｃ－ｍｙｃ癌基因高表达占３７．５％，其中１９例有不典型增生的癌旁上皮，高表达占７８．９５％，而无不典型增生的癌分上皮高表达只占１０．３４％。结果提示Ｃ－ｍｙｃ癌基因的高表达与胃粘膜上皮的异型增生有关，与胃癌的临床预后的关系还有待进一步探索。

The expression of C-myc gene in gastric carcinoma and premalignant gastric disorder

Seventy cases of gastric carcinoma and gastrosis have been studied using in situ hybridization technique with biotin labeled probs, including 48 gastric carcinoma samples, 14 chronic gastritis samples, 5 atrophic gastritis samples, one peptic ulcer and 2 normal samples. Elevated of C-myc mRNA expression was found in 29 out of 48 cases (60. 42% ) of the gastric carcinoma, and also in 6 out of 22 cases (27. 27%) of gastric disorder. The expression of C-myc gene was significantly higher in carcinoma than in benign tissues (P<0. 05). The 6 cases with high level of expression of C-myc gene were all found in chronic gastritis with dysplasia (46. 15%). There were nosignificant difference between dysplasia and carcinoma.High level expression of C-myc gene was observed in the epithelium of adjacent to carcinoma (37. 5%). However, the epithelium with dysplasia showed over-expression in 15 out of 19 (78.95% ). It was much higher than that in the normal epithelium (P<0. 01). In our study, the expression of C-myc gene did not correlate with the histological types of differenation of gastric carcinoma, site of tumor, serosal involvement, lymph node matastasis and peritoneal dissemination. From the result, it appears that the dysplasitic epithlium are closely related to gastric carcinoma and over-expression of C-myc gene may play a role in the carcinogenesis of this cancer.