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Cognitive Impairment and Psychiatric Morbidity in HIV+ Zambians with New-Onset Seizure
Authors:Lisa Kalungwana  Melissa A Elafros  Omar K Siddiqi  Christopher M Bositis  Izukanji Sikazwe  Igor J Koralnik  William H Theodore  Gretchen L Birbeck
Abstract:A prospective cohort study of new-onset seizure in people with human immunodeficiency virus (HIV) in Zambia is ongoing to determine the incidence of subsequent epilepsy and risk factors for epileptogenesis in this population. At enrollment, we evaluated this cohort for cognitive impairment and psychiatric morbidity. Over 50% of participants had cognitive impairment and significant psychiatric morbidity. Most participants had advanced HIV disease based on CD4+ T-cell count and World Health Organization stage, but we found no association between cognitive impairment or psychiatric morbidity and HIV disease staging.
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