阿司匹林联合低分子肝素对重度子痫前期孕妇血液高凝状态及妊娠结局的影响

目的探讨阿司匹林联合低分子肝素对重度子痫前期孕妇血液高凝状态及妊娠结局的影响。方法选取2016年9月至2018年12月我院收治的重度子痫前期孕妇70例,随机分为两组各35例。在常规药物治疗基础上,对照组给予阿司匹林治疗,观察组给予阿司匹林联合低分子肝素治疗,比较两组的妊娠结局及治疗前后的凝血功能指标。结果治疗前,两组的凝血功能指标比较,差异无统计学意义(P>0.05);治疗后,观察组的PT、APTT显著高于对照组,FIB、DD显著低于对照组(P<0.05)。治疗后,观察组的早产、产后出血、胎儿窘迫及新生儿窒息发生率显著低于对照组(P<0.05)。结论阿司匹林联合低分子肝素治疗重度子痫前期孕妇可有效改善血液高凝状态,减少不良妊娠结局,从而保障孕妇及胎儿的健康。

Effect of Aspirin Combined with Low-Molecular-Weight Heparin on the Blood Hypercoagulation State and Pregnancy Outcomes of Pregnant Women with Severe Preeclampsia

Objective To explore the effect of aspirin combined with low-molecular-weight heparin on the blood hypercoagulation state and pregnancy outcomes of pregnant women with severe preeclampsia.Methods 70 pregnant women with severe preeclampsia admitted to our hospital from September 2016 to December 2018 were selected and randomly divided into two groups,with 35 cases in each group.On the basis of regular medication therapy,the control group was treated with aspirin,and the observation group was treated with aspirin combined with low-molecular-weight heparin.The coagulation indicators before and after treatment,and the pregnancy outcome were compared between two groups.Results Before treatment,no statistical difference was found in the coagulation indicators between the two groups(P>0.05);After treatment,the PT and APTT of the observation group was significantly higher than those of the control group,and the FIB and DD were significantly lower than those of the control group(P<0.05).After treatment,the incidence of preterm delivery,postpartum hemorrhage,fetal distress and neonatal asphyxia of the observation group were significantly lower than those of the control group(P<0.05).Conclusions Aspirin combined with low-molecular-weight heparin in the treatment of pregnant women with severe preeclampsia can effectively improve the blood hypercoagulation state and reduce the adverse pregnancy outcome,so as to ensure the health of pregnant women and fetus.