Distal Convoluted Tubule |
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| Authors: | Arohan R Subramanya David H Ellison |
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| Institution: | Departments of *Medicine and;†Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;;‡Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania;;Departments of §Medicine and;‖Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon; and;¶Portland Veterans Affairs Medical Center, Portland, Oregon |
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| Abstract: | The distal convoluted tubule is the nephron segment that lies immediately downstream of the macula densa. Although short in length, the distal convoluted tubule plays a critical role in sodium, potassium, and divalent cation homeostasis. Recent genetic and physiologic studies have greatly expanded our understanding of how the distal convoluted tubule regulates these processes at the molecular level. This article provides an update on the distal convoluted tubule, highlighting concepts and pathophysiology relevant to clinical practice. |
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| Keywords: | distal tubule Na transport potassium channels mineral metabolism renal physiology |
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