Autoimmune hepatitis as an adverse effect of long-term methotrexate therapy |
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| Authors: | Kamilia Ksouda Hanen Affes Rim Atheymen Mariem Ezzeddine Khaled Zeghal Serria Hammami |
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| Institution: | Department of Pharmacology, School of Medecine of Sfax, Tunisia;1.Department of Rheumatology, CHU Hedi Chaker Sfax, Tunisia |
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| Abstract: | Methotrexate (MTX) is one of the most commonly used medicines in the treatment of psoriatic arthritis. The drug can produce steatosis and cirrhosis. Autoimmune hepatitis is a rare and serious adverse effect. We describe the case of a 53-year-old woman who developed autoimmune hepatitis after a long-term use of MTX for psoriatic arthritis. Hepatitis was completely resolved 4 months after stopping this drug. The pathophysiologic mechanisms of a drug-induced autoimmunity are unclear and complex. This report confirms the need to monitor liver enzymes carefully in patients using long-term treatment with MTX for psoriasis or rheumatoid arthritis.KEY WORDS: Autoimmune hepatitis, drug-induced autoimmunity, methotrexate, psoriatic arthritis |
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