髓核对背根节的损伤以及与痛觉过敏的关系

目的 观念髓核组织对背根节(DRG)的损伤作用，探讨这种损伤作用与痛觉过敏之间的关系。方法 从鼠尾椎间盘取髓核组织移植到神经根，使用神经行为学的方法观测痛觉过敏，大体、光镜和电镜相结合观测组织学改变。结果 术后实验侧后肢出现明显的痈觉过敏，并义术后1周最明显；组织学观察发现髓核组织使DRG出现水肿、炎细胞浸润，DRG神经元出现溶酶体增多、线粒体肿胀等损伤表现，术后1周表现最明显。结论 髓核组织对DRG有炎性损伤作用，此损伤作用与痛觉过敏可能存在联系。

The injuries to the dorsal root ganglion derived by nucleus pulposus and the relationship between the injuries and the hyperalgesia

Objective To observe the injuries to the dorsal root ganglion(DRG) derived by auto transplantation of nucleus pulposus and find out the relationship between the injuries and the hyperalgesia.Method We harvest the nucleus pulposus from the tails of rats and transplant it to the peripheral of the same rat's lumbar nerve roots. Using behavior test we research the hyperalgesia derived by nucleus pulposus. Using microscope and electron microscope we try to find out the histological changes.Results With the stimulation of nucleus pulposus, hyperalgesia appears at the related hindlimb of rat, especially in 1 week after surgery. Edema ,inflammation, lysosome increasing and mitochondrion swelling are found especially in 1 week after surgery too.Conclusion Nucleus pulposus can injure the DRG. These injuries perhaps are related to the hyperalgesia.