十二指肠溃疡病患者幽门螺旋菌感染与胃酸及胃泌素关系

４０例活动性十二指肠球部溃疡病人均伴有胃窦炎，２８例胃窦部幽门螺旋菌阳性，１２例阴性，基础胃酸分泌，五肽胃泌素刺激后的高峰胃酸分泌以及空腹和餐后１小时血清胃泌素水平。在ＨＰ＋）组均明显高于ＨＰ（－）组（Ｐ＜０．０１－０．０２）。经治疗，１０例ＨＰ（＋）患者复查，发现ＨＰ清除后空腹和餐后血清胃泌素均显著下降（＜０．０１），但平均ＢＡＯ和ＰＡＯ下降不明显（Ｐ＞０．０５）。研究结果提示，ＨＰ系通过刺激胃

ANTRAL HELICOBACTER PYLORI, GASTRIN AND GASTRIC ACID SECRETION IN PATIENTS WITH DUODENAL ULCERS

We studied 40 patients with active duodenal ulcers,all of them had antrum gastritis,28were positive for Helicobacter pylori and 12 hegative on antrum. Basal acid output (BAO),peak secretion of acid stim ulated by pen tagastrin (PAO),Basal serum gastrin and postprandial serum gastrin concentrations are measured.The four items are significantly higher in patients positive for H pylori than in those negative for the organigm. Arter treatment,9 paticnts eradicatcs H pylori,Basal grastrin and postprandial gastrin concentrations fell,However,BAO and PAO unchanged.Therefore,H pylori increasc antral gastrin relapse and gastric acid secretion,then causes duodenal ulcers.Using treatments that eradicate H pylori and H2-receptor's antogonist,We will cure duodenal ulcer faster.