| 载基因壳聚糖纳米粒的研究 |
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| 引用本文： | 赵惠萍,高奋,肖传实.载基因壳聚糖纳米粒的研究[J].国际生物医学工程杂志,2008,31(5). |
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| 作者姓名： | 赵惠萍 高奋 肖传实 |
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| 作者单位： | 1. 山西医科大学第二临床医学院,太原,030001
2. 山西医科大学第二医院,太原,030001 |
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| 基金项目： | 山西省留学归国人员重点基金 |
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| 摘 要： | RNA干扰技术已被广泛应用于心血管领域,壳聚糖纳米粒以其良好的生物特性而作为基因递送载体成为现在研究的热点.就BNA干扰技术与纳米技术在心血管领域的应用及目前常采用的制备壳聚糖纳米粒的方法、影响质粒与壳聚糖纳米粒结合效率的因素、质粒壳聚糖复合物纳米粒转染的影响因素及体外释药行为作一简单的回顾.
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| 关 键 词： | RNA干扰 壳聚糖 纳米 质粒壳聚糖复合物纳米粒 |
Research of chitosan nanoparticles loaded with gene |
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| ZHAO Hui-ping,GAO Fen,XIAO Chuan-shi.Research of chitosan nanoparticles loaded with gene[J].International Journal of Biomedical Engineering,2008,31(5). |
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| Authors: | ZHAO Hui-ping GAO Fen XIAO Chuan-shi |
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| Abstract: | The technique of RNA interference has been used in the area of cardiovascular system. Chitosan nanoparticles(CS-NP) has been a hotspot of the research due to its good biological characteristics and has a great potential to be used as the carrier for gene delivery. This article gives a simple review the application of the techniques, the currently used preparation methods of CS-NP, the factors that affect the rate of complexing of plasmid with CS-NP, the transfection efficiency of plasmid CS-NP compounds, and its in vitro drug releasing behavior. |
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| Keywords: | RNA interference Chitosan Nanoparticles Plasmid CS-NP compounds |
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