| Study on the protective mechanism of remifentanil on mitochondria in rat hepatocytes subjected to ischemia-reperfusion injury |
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| 作者姓名： | 郝雪琴 陶国才 崔剑 易斌 陈毅飞 |
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| 作者单位： | Department of Anesthesiology, Southwest Hospital, Third Military Medical University, Chongqing 400038,China |
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| 摘 要： | Objective：To explore the protective effect of remifentanil on mitochondria in rat hepatocytes subjected to ischemia-reperfusion injury and their possible mechanism. Methods：The model of rat hepatic ischemia-reperfusion injury was used and the effect of remifentanil on the ultrastructure of mitochondria, calcium homeostasis, MDA level in mitochondria were observed. Results： In contrast with the control group, mitochondrial matrix calcium concentration, calcium concentration after calcium uptake, and the quantity of calcium uptake in low and high remifentanil concentration groups and 5-HD group are lower （P〈0.01）, and there is no difference in RHD （5-HD＋remifentanil） group. The difference in MDA level between groups is insignificant. Conclusion ：Remifentanil at clinical concentrations exerts a protective effect on mitochondria in rat hepatocytes subjected to ischemia-reperfusion injury, in which activating the KATP channel may be involved.
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| 关 键 词： | 保护机制 线立体 肝细胞 缺血再灌注损伤 |
| 收稿时间： | 2005-10-11 |
| 修稿时间： | 2006-01-15 |
Study on the protective mechanism of remifentanil on mitochondria in rat hepatocytes subjected to ischemia-reperfusion injury |
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| HAO Xue-qin,TAO Guo-cai,CUI Jian,YI Bin,CHEN Yi-fei.Study on the protective mechanism of remifentanil on mitochondria in rat hepatocytes subjected to ischemia-reperfusion injury[J].Journal of Medical Colleges of PLA(China),2006,21(2):122-124. |
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| Authors: | HAO Xue-qin TAO Guo-cai CUI Jian YI Bin CHEN Yi-fei |
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| Abstract: | Objective:To explore the protective effect of remifentanil on mitochondria in rat hepatocytes subjected to ischemia-reperfusion injury and their possible mechanism. Methods:The model of rat hepatic ischemia-reperfusion injury was used and the effect of remifentanil on the ultrastructure of mitochondria, calcium homeostasis, MDA level in mitochondria were observed. Results: In contrast with the control group, mitochondrial matrix calcium concentration, calcium concentration after calcium uptake, and the quantity of calcium uptake in low and high remifentanil concentration groups and 5-HD group are lower (P<0. 01), and there is no difference in RHD (5-HD+remifentanil) group. The difference in MDA level between groups is insignificant. Conclusion:Remifentanil at clinical concentrations exerts a protective effect on mitochondria in rat hepatocytes subjected to ischemia-reperfusion injury, in which activating the KATP channel may be involved. |
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| Keywords: | remifentanil ischemia-reperfusion injury calcium mitochondria liver |
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