| 丹参酮I固体脂质纳米粒的制备及评价 |
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| 引用本文： | 张谦,刘志东,秦璐,顾星,冯光维.丹参酮I固体脂质纳米粒的制备及评价[J].天津中医药大学学报,2016,35(2):118-121. |
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| 作者姓名： | 张谦 刘志东 秦璐 顾星 冯光维 |
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| 作者单位： | 天津中医药大学, 现代中药发现与制剂技术教育部工程研究中心, 天津 300193;天津中医药大学, 天津市现代中药重点实验室一省部共建国家重点实验室培育基地, 天津 300193,天津中医药大学, 现代中药发现与制剂技术教育部工程研究中心, 天津 300193;天津中医药大学, 天津市现代中药重点实验室一省部共建国家重点实验室培育基地, 天津 300193,天津中医药大学, 现代中药发现与制剂技术教育部工程研究中心, 天津 300193;天津中医药大学, 天津市现代中药重点实验室一省部共建国家重点实验室培育基地, 天津 300193,天津中医药大学, 现代中药发现与制剂技术教育部工程研究中心, 天津 300193;天津中医药大学, 天津市现代中药重点实验室一省部共建国家重点实验室培育基地, 天津 300193,天津中医药大学, 现代中药发现与制剂技术教育部工程研究中心, 天津 300193;天津中医药大学, 天津市现代中药重点实验室一省部共建国家重点实验室培育基地, 天津 300193 |
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| 基金项目： | 新世纪优秀人才支持计划(NCET-12-1068)。 |
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| 摘 要： | 目的] 制备丹参酮I固体脂质纳米粒(TSI-SLN)并对其性质质量进行考察。方法] TSI-SLN的制备方法选用乳化固化法,并以制剂的粒径、电位和包封率为考察指标。对TSI-SLN冻干品进行差式扫描量热法(DSC)检测。结果] TSI-SLN的平均粒径为(128±2.00)nｍ,电位为(-9.35±0.12)mV;TSI的包封率为(74.03±1.32)%。DSC结果表明丹参酮I包裹在纳米粒中。结论] 采用乳化固化法安全可靠,简单易行;该方法下制备的SLN具有较小的粒径和较高的包封率;且理化性质稳定,为后续实验提供了依据。
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| 关 键 词： | 丹参酮I 固体脂质纳米粒 制备 评价 |
| 收稿时间： | 2015/11/18 0:00:00 |
Preparation and evaluation of Tanshinone I solid lipid nanoparticles |
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| ZHANG Qian,LIU Zhi-dong,QIN Lu,GU Xing and FENG Guang-wei.Preparation and evaluation of Tanshinone I solid lipid nanoparticles[J].Journal of Tianjin University of Traditonal Chinese Medicine,2016,35(2):118-121. |
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| Authors: | ZHANG Qian LIU Zhi-dong QIN Lu GU Xing and FENG Guang-wei |
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| Institution: | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of TCM, Tianjin 300193, China;Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China,Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of TCM, Tianjin 300193, China;Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China,Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of TCM, Tianjin 300193, China;Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China,Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of TCM, Tianjin 300193, China;Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China and Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of TCM, Tianjin 300193, China;Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of TCM, Tianjin 300193, China |
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| Abstract: | Objective] To prepare Tanshinone I solid lipid nanoparticles (TSI-SLN) and investigate the physicochemical properties.Methods] TSI-SLN were prepared by using emulsion evaporation-solidification method, and the particle size, Zeta potential and encapsulation efficiency(EE) were determined. And the solid-state characterization ofthe TS I-SLN was analyzed by DSC.Results] The results showed that the TS I-SLN had average particle size of (128±2.00) nm, zeta potential of (-9.35±0.12) mV and the encapsulation efficiency of (74.03±1.32)%, respectively. DSC results indicated that the drug wrapped in nanoparticles completely.Conclusion] In this paper, emulsion evaporation-solidification method has chosen for the preparation. The TS I-SLN has superior physical and chemical properties |
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| Keywords: | Tanshinone I solid lipid nanoparticles preparation evaluation |
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