| 颐和春口服液对肾阳虚大鼠睾丸功能的影响 |
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| 引用本文： | 朱善意,高越颖,陈爽,刘玲艳,冯磊,邱丽颖.颐和春口服液对肾阳虚大鼠睾丸功能的影响[J].中药新药与临床药理,2010,21(2). |
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| 作者姓名： | 朱善意 高越颖 陈爽 刘玲艳 冯磊 邱丽颖 |
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| 作者单位： | 1. 江南大学医药学院生物制药系,江苏无锡214122;江苏省姜堰市苏中制药集团有限公司,江苏姜堰225500
2. 江南大学医药学院生物制药系,江苏无锡,214122 |
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| 摘 要： | 目的观察颐和春口服液对肾阳虚大鼠睾丸功能的影响并探讨其机制。方法用腺嘌呤制备肾阳虚大鼠模型。实验分为正常对照组、肾阳虚模型组、阳性药物治疗组和颐和春治疗组。观察颐和春口服液对肾阳虚大鼠睾丸形态学、血清雄性激素及睾丸组织MDA和SOD的影响,并观察对腺垂体细胞凋亡及下丘脑区兴奋性及抑制性氨基酸比值的影响。HE染色观察睾丸形态学改变、放免法测定血清雄性激素、生化法测定睾丸组织MDA和SOD,末端标记法测定腺垂体细胞凋亡,HPLC测定脑组织氨基酸。结果颐和春明显改善肾阳虚引起的睾丸损伤,提高雄性激素水平,降低睾丸组织MDA,提高SOD,减少腺垂体细胞凋亡,调节下丘脑兴奋性和抑制性氨基酸比值。结论颐和春口服液对肾阳虚大鼠生殖能力有一定改善作用,可能与其对下丘脑-腺垂体-睾丸轴的调节作用有关。
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| 关 键 词： | 颐和春口服液 肾阳虚 睾丸功能 下丘脑-腺垂体-性腺轴 |
Effects of Yihechun Oral Liquid on Testicular Function of Kidney-yang Deficiency Rats |
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| ZHU Shanyi,GAO Yueying,CHEN Shuang,LIU Lingyan,FENG Lei,QIU Liying.Effects of Yihechun Oral Liquid on Testicular Function of Kidney-yang Deficiency Rats[J].Traditional Chinese Drug Research & Clinical Pharmacology,2010,21(2). |
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| Authors: | ZHU Shanyi GAO Yueying CHEN Shuang LIU Lingyan FENG Lei QIU Liying |
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| Institution: | ZHU Shanyi1,2,GAO Yueying1,CHEN Shuang1,LIU Lingyan1,FENG Lei1,QIU Liying1(1.Department of BioPharmaceutics,School of Medicine , Pharmaceutics,Jiangnan University,Wuxi 214122 Jiangsu,China,2.Suzhong Pharmaceutical Group Co.,Ltd.,Jiangyan 225500 Jiangsu,China) |
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| Abstract: | Objective To observe the effect of Yihechun oral liquid(YOL)on testicular function of kidney-yang deficiency rats and to explore its mechanism.Methods The kidney-yang deficiency rat model was induced by gastric infusion of adenine.The rats were divided into four groups:normal control group,kidney-yang deficiency model group,positive drug group,and YOL group.We observed the effect of YOL on testis morphology,serum androgen level,MDA and SOD activities in testicular tissue.Meanwhile,the apoptosis of adenopitu... |
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| Keywords: | Yihechun oral liquid Kidney-yang deficiency Testicular function Hypothalamus - pituitary - testicular axis |
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